2. Gene
  3. Sorl1 - sortilin-related receptor, LDLR class A repeats-containing Gene

Sorl1 - sortilin-related receptor, LDLR class A repeats-containing Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: LR11; SorLA; gp250; mSorLA; 2900010L19Rik

基因 ID: 20660 | 基因类型: protein coding

关于 Sorl1

功能概要

Predicted to enable several functions, including low-density lipoprotein particle binding activity; peptide binding activity; and small GTPase binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of protein metabolic process; and regulation of signal transduction. Located in extracellular space; nuclear envelope lumen; and perinucleolar compartment. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sorl1 基因产物(2)

mRNA Protein Name
NM_001357261.1 NP_001344190.1 sortilin-related receptor isoform 2
NM_011436.4 NP_035566.2 sortilin-related receptor isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type endopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
18362153 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16407538 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adaptive thermogenesis IMP
IMP: 通过突变表型推断
26584636 MGI
involved in diet induced thermogenesis IMP
IMP: 通过突变表型推断
26584636 MGI
involved in endosome to plasma membrane protein transport IDA
IDA: 通过直接分析推断
27322061 MGI
involved in insulin receptor recycling IDA
IDA: 通过直接分析推断
27322061 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
26584636 MGI
involved in negative regulation of amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
18362153 MGI
involved in negative regulation of amyloid-beta formation IMP
IMP: 通过突变表型推断
18362153 MGI
involved in negative regulation of neurofibrillary tangle assembly IMP
IMP: 通过突变表型推断
22986780 MGI
involved in negative regulation of neurogenesis IMP
IMP: 通过突变表型推断
18362153 MGI
involved in negative regulation of triglyceride catabolic process IMP
IMP: 通过突变表型推断
27322061 MGI
involved in positive regulation of adipose tissue development IMP
IMP: 通过突变表型推断
27322061 MGI
involved in positive regulation of glial cell-derived neurotrophic factor production IMP
IMP: 通过突变表型推断
21994944 MGI
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
27322061 MGI
involved in protein retention in Golgi apparatus IMP
IMP: 通过突变表型推断
18362153 MGI
involved in protein targeting IDA
IDA: 通过直接分析推断
27322061 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11082041 MGI
located in membrane IDA
IDA: 通过直接分析推断
11082041 MGI
located in nuclear envelope lumen IDA
IDA: 通过直接分析推断
18362153 MGI
located in perinucleolar compartment IDA
IDA: 通过直接分析推断
11082041 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sortilin-related receptor

LDLR relative with 11 ligand-binding repeats

low-density lipoprotein receptor relative with 11 ligand-binding repeats

sorLA-1

sorting protein-related receptor containing LDLR class A repeats

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13574 SORL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21763 Sorl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sorl1 NCBI NCBI:6653
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