Sox2 - SRY (sex determining region Y)-box 2 Gene

种属: Mus musculus

同用名: lcc; ysb; Sox-2

基因 ID: 20674 | 基因类型: protein coding

关于 Sox2

功能概要

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]

Sox2 基因产物(1)

mRNA	Protein	Name
NM_011443.4	NP_035573.3	transcription factor SOX-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	8625802	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	7628452	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	22344693	MGI
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	21076177	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12665572	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: 通过遗传相互作用推断	15863505	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	25901318	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	24268575	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15988017	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	7590241	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	7628452	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19328208	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of Notch signaling pathway	IDA IDA: 通过直接分析推断	16631155	MGI
acts upstream of Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	15781477	MGI
acts upstream of or within adenohypophysis development	IMP IMP: 通过突变表型推断	16932809	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: 通过突变表型推断	9851841	MGI
acts upstream of or within cell fate commitment	IDA IDA: 通过直接分析推断	18374910	MGI
acts upstream of or within cell fate specification	IMP IMP: 通过突变表型推断	12514105	MGI
acts upstream of or within cellular response to cadmium ion	IDA IDA: 通过直接分析推断	15219627	MGI
acts upstream of or within cerebral cortex development	IMP IMP: 通过突变表型推断	15240551	MGI
acts upstream of or within detection of mechanical stimulus involved in equilibrioception	IMP IMP: 通过突变表型推断	15846349	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: 通过突变表型推断	15846349	MGI
acts upstream of or within diencephalon morphogenesis	IMP IMP: 通过突变表型推断	15240551	MGI
acts upstream of or within embryonic organ development	IMP IMP: 通过突变表型推断	17522155	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IDA IDA: 通过直接分析推断	18374910	MGI
acts upstream of or within forebrain neuron differentiation	IMP IMP: 通过突变表型推断	15240551	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	17267691	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: 通过突变表型推断	15846349	MGI
acts upstream of or within lens induction in camera-type eye	IGI IGI: 通过遗传相互作用推断	17140559	MGI
acts upstream of or within lung alveolus development	IDA IDA: 通过直接分析推断	18374910	MGI
acts upstream of or within male genitalia development	IMP IMP: 通过突变表型推断	16932809	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	15781477	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	17875931	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: 通过突变表型推断	17507372	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: 通过直接分析推断	16631155	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	15781477	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	9649510	MGI
acts upstream of neuroblast proliferation	IMP IMP: 通过突变表型推断	15240551	MGI
acts upstream of neuron differentiation	IDA IDA: 通过直接分析推断	16631155	MGI
acts upstream of neuron differentiation	IMP IMP: 通过突变表型推断	16651659	MGI
acts upstream of or within neuron fate commitment	IMP IMP: 通过突变表型推断	17015430	MGI
involved in neuronal stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	22198669	MGI
acts upstream of or within olfactory placode formation	IGI IGI: 通过遗传相互作用推断	17140559	MGI
acts upstream of osteoblast differentiation	IDA IDA: 通过直接分析推断	15781477	MGI
acts upstream of or within pigment biosynthetic process	IMP IMP: 通过突变表型推断	12036291	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IDA IDA: 通过直接分析推断	16631155	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: 通过直接分析推断	18374910	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: 通过突变表型推断	15240551	MGI
acts upstream of or within positive regulation of neuron differentiation	IMP IMP: 通过突变表型推断	16651659	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7628452	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	26691508	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	7590241	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15988017	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12665572	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: 通过遗传相互作用推断	22513373	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19796622	MGI
acts upstream of or within response to retinoic acid	IDA IDA: 通过直接分析推断	18400104	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: 通过突变表型推断	16651659	MGI
acts upstream of or within sensory perception of sound	IMP IMP: 通过突变表型推断	12036291	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	16767105	MGI
acts upstream of or within stem cell differentiation	IDA IDA: 通过直接分析推断	20123909	MGI
involved in stem cell population maintenance	IMP IMP: 通过突变表型推断	23169531	MGI
acts upstream of or within tongue development	IMP IMP: 通过突变表型推断	17015430	MGI
acts upstream of trophectodermal cell differentiation	IMP IMP: 通过突变表型推断	17507372	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in chromatin	IDA IDA: 通过直接分析推断	23798425	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	9512512	MGI
located in nucleus	IDA IDA: 通过直接分析推断	9512512	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	17507372	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transcription factor SOX-2

SRY-box containing gene 2

Sox2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Sox2	Q60I23	Chd4	Mus musculus	Q6PDQ2	Anti Bait CoIP	21532573
种属内	Sox2	Q60I23	Chd4	Mus musculus	Q6PDQ2	Anti Tag CoIP	21532573
种属内	Sox2	Q60I23	Chd7	Mus musculus	A2AJK6	Anti Tag CoIP	21532573
种属内	Sox2	Q60I23	Chd7	Mus musculus	A2AJK6	Anti Bait CoIP	21532573

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12303	OAC1	Activator	99.85%	否
HY-B1238	Pronethalol	Inhibitor	99.88%	否
HY-150082	CP681301	Inhibitor	99.18%	否
HY-18772	O4I2	Activator	99.18%	否
HY-RS13591	SOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-173076A	HDAC11-IN-1 TFA	Inhibitor	99.25%	否
HY-15313B	CBB1007 hydrochloride	Inhibitor	98.0%	否
HY-143443	DS17701585	Inhibitor	/	否
HY-129108	9-cis-UAB30		/	否
HY-132974	Aminoflavone		/	否
HY-165606	SB-T-1214	Inducer	/	否
HY-168885	ZSH-512		/	否
HY-173076	HDAC11-IN-1	Inhibitor	/	否
HY-175164	SVC112		/	否
HY-179339	LSD1-IN-46	Inhibitor	/	否
HY-B1238A	Pronethalol hydrochloride	Inhibitor	/	否
HY-119666	Rooperol	Activator	/	否
HY-174539	Human SOX2 mRNA		/	否
HY-N15201	Betavulgarin	Inhibitor	/	否
HY-RS16652	Sox2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23087	Sox2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24311	Qsox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Sox2	NCBI	NCBI:6657

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3