2. Gene
  3. Srebf2 - sterol regulatory element binding factor 2 Gene

Srebf2 - sterol regulatory element binding factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc

基因 ID: 20788 | 基因类型: protein coding

关于 Srebf2

功能概要

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within Cholesterol homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Srebf2 基因产物(2)

mRNA Protein Name
NM_001411792.1 NP_001398721.1 sterol regulatory element-binding protein 2 isoform 2
NM_033218.2 NP_150087.1 sterol regulatory element-binding protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11829742 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11739104 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
33942715 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
11739104 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cholesterol homeostasis IGI
IGI: 通过遗传相互作用推断
20466882 MGI
involved in positive regulation of cholesterol biosynthetic process IMP
IMP: 通过突变表型推断
33942715 MGI
involved in positive regulation of miRNA transcription IDA
IDA: 通过直接分析推断
23823476 MGI
involved in positive regulation of myelination IMP
IMP: 通过突变表型推断
33942715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16890542 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12242332 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16100574 MGI
located in membrane IDA
IDA: 通过直接分析推断
11090130 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10397761 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sterol regulatory element-binding protein 2

sterol regulatory element-binding transcription factor 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13758 SREBF2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-179526 Sino-C / 否
HY-RS21946 Srebf2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srebf2 NCBI NCBI:6721
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