2. Gene
  3. Thrb - thyroid hormone receptor beta Gene

Thrb - thyroid hormone receptor beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta

基因 ID: 21834 | 基因类型: protein coding

关于 Thrb

功能概要

Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (Thyroid Hormone Receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Thrb 基因产物(2)

mRNA Protein Name
NM_001113417.1 NP_001106888.1 thyroid hormone receptor beta isoform 1
NM_009380.3 NP_033406.1 thyroid hormone receptor beta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
17952069 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22079090 MGI
enables nuclear receptor activity IMP
IMP: 通过突变表型推断
20203194 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9405624 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
9927422 MGI
acts upstream of or within female courtship behavior IMP
IMP: 通过突变表型推断
10769387 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15062575 MGI
acts upstream of or within negative regulation of female receptivity IMP
IMP: 通过突变表型推断
10769387 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
7566114 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
12407160 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
9832432 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19052228 MGI
acts upstream of or within retinal cone cell apoptotic process IMP
IMP: 通过突变表型推断
20203194 MGI
acts upstream of retinal cone cell development IMP
IMP: 通过突变表型推断
20203194 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
8673137 MGI
acts upstream of or within type I pneumocyte differentiation IGI
IGI: 通过遗传相互作用推断
22001906 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
17952069 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thyroid hormone receptor beta

TR beta

c-erbA-2

c-erbA-beta

nuclear receptor subfamily 1 group A member 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14501 THRB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20346 Thrb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26855 Thrb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Thrb NCBI NCBI:7068
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