2. Gene
  3. Trim28 - tripartite motif-containing 28 Gene

Trim28 - tripartite motif-containing 28 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KAP-1; Tif1b; KRIP-1; MommeD9; Tif1beta

基因 ID: 21849 | 基因类型: protein coding

关于 Trim28

功能概要

Enables DNA binding activity; protein kinase activity; and transcription coactivator activity. Involved in epithelial to mesenchymal transition and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation involved in embryo development; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of nucleobase-containing compound metabolic process. Located in euchromatin; heterochromatin; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb primordium. Orthologous to human TRIM28 (tripartite motif containing 28). [provided by Alliance of Genome Resources, Apr 2022]

Trim28 基因产物(1)

mRNA Protein Name
NM_011588.3 NP_035718.2 transcription intermediary factor 1-beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
22442485 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8978696 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
10562550 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
11331592 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within convergent extension involved in axis elongation IMP
IMP: 通过突变表型推断
22110054 MGI
acts upstream of or within embryo implantation IMP
IMP: 通过突变表型推断
22442485 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: 通过突变表型推断
22110054 MGI
acts upstream of or within epigenetic programming of gene expression IMP
IMP: 通过突变表型推断
22442485 MGI
involved in epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
17273560 MGI
acts upstream of or within genomic imprinting IMP
IMP: 通过突变表型推断
22442485 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
22442485 MGI
acts upstream of or within innate immune response IDA
IDA: 通过直接分析推断
19270682 MGI
acts upstream of or within innate immune response IGI
IGI: 通过遗传相互作用推断
19270682 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10562550 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21518874 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: 通过直接分析推断
19270682 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IGI
IGI: 通过遗传相互作用推断
19270682 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: 通过突变表型推断
19270682 MGI
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: 通过突变表型推断
20164836 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8986806 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22110054 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: 通过直接分析推断
19270682 MGI
acts upstream of or within positive regulation of DNA binding IMP
IMP: 通过突变表型推断
19270682 MGI
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
20164836 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11331592 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17273560 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
10562550 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
10562550 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
17273560 MGI
located in chromatin IDA
IDA: 通过直接分析推断
11331580 MGI
located in euchromatin IDA
IDA: 通过直接分析推断
10562550 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
10562550 MGI
NOT located in nucleolus IDA
IDA: 通过直接分析推断
10562550 MGI
located in nucleoplasm IDA
IDA: 通过直接分析推断
10562550 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15469996 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription intermediary factor 1-beta

E3 SUMO-protein ligase TRIM28

KRAB-A-interacting protein

RING-type E3 ubiquitin transferase TIF1-beta

TIF1-beta

transcriptional intermediary factor 1, beta

tripartite motif protein 28

tripartite motif-containing protein 28

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15033 TRIM28 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-169086 KL-465 / 否
HY-175240 PROTAC BRD4 Degrader-38 Degrader / 否
HY-181157 T/E PPI-IN-1 Inhibitor / 否
HY-RS18012 Trim28 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24485 Trim28 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trim28 NCBI NCBI:10155
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