2. Gene
  3. Xpc - xeroderma pigmentosum, complementation group C Gene

Xpc - xeroderma pigmentosum, complementation group C Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 22591 | 基因类型: protein coding

关于 Xpc

功能概要

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and damaged DNA binding activity. Involved in UV-damage excision repair. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling; pyrimidine dimer repair by nucleotide-excision repair; and response to UV. Located in nucleus and site of DNA damage. Used to study lung Cancer and xeroderma pigmentosum group C. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Xpc 基因产物(1)

mRNA Protein Name
NM_009531.2 NP_033557.2 DNA repair protein complementing XP-C cells homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
25901318 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
25901318 MGI
enables damaged DNA binding IDA
IDA: 通过直接分析推断
22431748 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22431748 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
15010313 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
12555660 MGI
involved in UV-damage excision repair IDA
IDA: 通过直接分析推断
22431748 MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling IGI
IGI: 通过遗传相互作用推断
15533840 MGI
acts upstream of or within nucleotide-excision repair IDA
IDA: 通过直接分析推断
12815074 MGI
involved in nucleotide-excision repair IDA
IDA: 通过直接分析推断
22431748 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: 通过突变表型推断
9067411 MGI
acts upstream of or within pyrimidine dimer repair by nucleotide-excision repair IMP
IMP: 通过突变表型推断
17049932 MGI
acts upstream of or within response to UV-B IMP
IMP: 通过突变表型推断
15010313 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12815074 MGI
is active in site of DNA damage IDA
IDA: 通过直接分析推断
22431748 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA repair protein complementing XP-C cells homolog

p125

xeroderma pigmentosum group C-complementing protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-157784 XPC-7724 Inhibitor 99.46% 否
HY-157786 XPC-5462 Inhibitor 99.65% 否
HY-128772 XPC-6444 Inhibitor 98.93 否
HY-RS15885 XPC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20245 Xpc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26753 Xpc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xpc NCBI NCBI:7508
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