2. Gene
  3. FOXF2 - forkhead box F2 Gene

FOXF2 - forkhead box F2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 F2

种属: Homo sapiens

同用名: FKHL6; FREAC2; FREAC-2

基因 ID: 2295 | 基因类型: protein coding

关于 FOXF2

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:1,389,576-1,395,603 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in lung (RPKM 8.4), prostate (RPKM 6.0) and 13 other tissues.

功能概要

FOXF2 编码叉头框 F2，它是黑腹果蝇转录因子叉头的许多人类同系物之一。 FOXF2 在肺和胎盘中表达，并已显示可转录激活多个肺特异性基因。[RefSeq 提供，2008 年 7 月]

FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]

FOXF2 基因产物(1)

mRNA Protein Name
NM_001452.2 NP_001443.1 forkhead box protein F2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
7957066 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8626802 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
8626802 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
9722567 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8626802 GOA
enables TFIIB-class transcription factor binding IPI
IPI: 通过物理相互作用推断
9722567 GOA
enables general transcription initiation factor binding IPI
IPI: 通过物理相互作用推断
9722567 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7957066 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in genitalia development IMP
IMP: 通过突变表型推断
19276632 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8626802 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8626802 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
8626802 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
29374064 GOA
involved in regulation of protein polyubiquitination IDA
IDA: 通过直接分析推断
29374064 GOA
involved in roof of mouth development IMP
IMP: 通过突变表型推断
19276632 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9722567 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
9722567 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXF2 蛋白结构

Forkhead

Forkhead: Forkhead domain (100 - 192)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
蛋白主名 其他名称

forkhead box protein F2

forkhead-like 6

关联疾病

疾病名称 别名
Anterior Segment Dysgenesis 3

Iridogoniodysgenesis, Type 1

Irid1

Iridogoniodysgenesis Anomaly, Autosomal Dominant

Igda

ASGD3

Iris Hypoplasia With Glaucoma

Glaucoma Iridogoniodysplasia, Familial

Anterior Segment Dysgenesis 3, Multiple Subtypes

Iridogoniodysgenesis Type 1

Glaucoma Iridogoniodysgenesia

Igda Syndrome

Iridogoniodysgenesis Anomaly
Acrorenal Syndrome
Blepharophimosis
Axenfeld-Rieger Syndrome

Axenfeld Syndrome

Rieger Syndrome

Rieger Anomaly

Axenfeld Anomaly

Anomaly, Rieger'S

Hagedoom Syndrome

Rgs - Rieger Syndrome

Rieger'S Anomaly

Goniodysgenesis Hypodontia

Iridogoniodysgenesis With Somatic Anomalies

Ars

Axenfeld And Rieger Anomaly

Axra

Axrs

Rieger Eye Malformation Sequence
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment

Ncrna Disease

Non-Syndromic Congenital Retinal Non-Attachment

Pfvs

Phpv

Persistent Fetal Vasculature Syndrome
Orofacial Cleft

Cleft, Orofacial
Anterior Segment Dysgenesis

Anterior Segment Developmental Anomaly

Anterior Segment Mesenchymal Dysgenesis

Corneal Opacification And Other Ocular Anomalies

Sclerocornea With Other Ocular Anomalies

Asmd

Asod

Anterior Segment Ocular Dysgenesis

Foxe3-Related Ocular Disorder

Familial Ocular Anterior Segment Mesenchymal Dysgenesis

Dysgenesis, Anterior Segment

Irido-Corneal Dysgenesis

Axenfeld-Rieger Syndrome, Type 3
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05050 FOXF2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FOXF2 VGNC VGNC:29085
Rattus norvegicus FOXF2 RGD RGD:1589717
Mus musculus FOXF2 MGD MGI:1347479
Felis catus FOXF2 VGNC VGNC:62333
Macaca mulatta FOXF2 VGNC VGNC:83424
Canis familiaris FOXF2 VGNC VGNC:40950
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