2. Gene
  3. PHLDA3 - pleckstrin homology like domain family A member 3 Gene

PHLDA3 - pleckstrin homology like domain family A member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：pleckstrin 同源性样域家族 A 成员 3

种属: Homo sapiens

同用名: TIH1

基因 ID: 23612 | 基因类型: protein coding

关于 PHLDA3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,464,278-201,469,188 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 2 paralogues. Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues.

功能概要

启用磷脂酰肌醇磷酸结合活性和磷脂酰肌醇-3,4-二磷酸结合活性。参与响应 p53 类介质对 DNA 损伤的内在凋亡信号通路；蛋白激酶 B 信号的负调节；和细胞凋亡过程的正调控。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PHLDA3 基因产物(1)

mRNA Protein Name
NM_012396.5 NP_036528.1 pleckstrin homology-like domain family A member 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: 通过直接分析推断
19203586 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: 通过直接分析推断
19203586 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
19203586 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
19203586 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
19203586 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pleckstrin homology-like domain family A member 3

TDAG51/Ipl homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10444 PHLDA3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PHLDA3 VGNC VGNC:106471
Mus musculus PHLDA3 MGD MGI:1351485
Felis catus PHLDA3 VGNC VGNC:107911
Bos taurus PHLDA3 VGNC VGNC:106865
Rattus norvegicus PHLDA3 RGD RGD:1310502
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