ARHGAP8 - Rho GTPase activating protein 8 Gene

中文名称：Rho GTP 酶激活蛋白 8

种属: Homo sapiens

同用名: PP610; BPGAP1

关于 ARHGAP8

功能概要

该基因编码 RHOGAP 家族的一个成员。 GAP (激活 GTP 酶) 家族蛋白参与调节细胞骨架变化所涉及的细胞过程的信号通路。 GAP 蛋白根据细胞中的 GTP:GDP 比率在活性 (GTP 结合) 和非活性 (GDP 结合) 状态之间交替。该家族成员是一种多结构域蛋白，可促进 ERK 激活和细胞运动。可变剪接导致多个转录本变体。从上游富脯氨酸 5，肾 (PRR5) 基因到该基因的通读转录本也存在，这导致最初将 PRR5 和 ARHGAP8 描述为单个基因。[RefSeq 提供，2010 年 11 月]

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote ERK activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]