2. Gene
  3. Gdf7 - growth differentiation factor 7 Gene

Gdf7 - growth differentiation factor 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BMP12

基因 ID: 238057 | 基因类型: protein coding

关于 Gdf7

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]

Gdf7 基因产物(2)

mRNA Protein Name
NM_001312876.1 NP_001299805.1 growth/differentiation factor 7 isoform 1 preproprotein
NM_013527.1 NP_038555.1 growth/differentiation factor 7 isoform 2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16049014 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12741987 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
16049014 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
16049014 MGI
acts upstream of or within axon guidance IDA
IDA: 通过直接分析推断
12639970 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
11356025 MGI
acts upstream of or within cell fate commitment IDA
IDA: 通过直接分析推断
15883363 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: 通过突变表型推断
11356025 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: 通过突变表型推断
10693795 MGI
acts upstream of or within gland morphogenesis IMP
IMP: 通过突变表型推断
11356025 MGI
acts upstream of or within midbrain development IMP
IMP: 通过突变表型推断
10693795 MGI
acts upstream of or within morphogenesis of an epithelial fold IMP
IMP: 通过突变表型推断
11356025 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
10693795 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
21412429 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
9786991 MGI
involved in positive regulation of tendon cell differentiation IDA
IDA: 通过直接分析推断
21412429 MGI
acts upstream of or within reproductive structure development IMP
IMP: 通过突变表型推断
11356021 MGI
acts upstream of or within roof plate formation IMP
IMP: 通过突变表型推断
10693795 MGI
acts upstream of or within spinal cord association neuron differentiation IMP
IMP: 通过突变表型推断
10693795 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
12741987 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

growth/differentiation factor 7

GDF-7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05357 GDF7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19900 Gdf7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26401 Gdf7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gdf7 NCBI NCBI:151449
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