2. Gene
  3. Sufu - SUFU negative regulator of hedgehog signaling Gene

Sufu - SUFU negative regulator of hedgehog signaling Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Su(fu)

基因 ID: 24069 | 基因类型: protein coding

关于 Sufu

功能概要

Enables beta-catenin binding activity. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of Hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]

Sufu 基因产物(2)

mRNA Protein Name
NM_001025391.2 NP_001020562.1 suppressor of fused homolog isoform 2
NM_015752.3 NP_056567.2 suppressor of fused homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IDA
IDA: 通过直接分析推断
11477086 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11252182 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within cytoplasmic sequestering of transcription factor IGI
IGI: 通过遗传相互作用推断
16316410 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
16155214 MGI
acts upstream of or within heart looping IMP
IMP: 通过突变表型推断
16155214 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
16459298 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
27234298 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16459298 MGI
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
19684112 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
16155214 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
16459298 MGI
acts upstream of smoothened signaling pathway IMP
IMP: 通过突变表型推断
16459298 MGI
acts upstream of negative effect smoothened signaling pathway IMP
IMP: 通过突变表型推断
29487109 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IMP
IMP: 通过突变表型推断
19684112 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IMP
IMP: 通过突变表型推断
19684112 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: 通过突变表型推断
16459298 MGI
acts upstream of or within ventricular septum development IMP
IMP: 通过突变表型推断
25807483 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
16254602 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
20360384 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16254602 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

suppressor of fused homolog

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-105634A Nomegestrol acetate Agonist 99.73% 是
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162273 Antibacterial agent 189 Inhibitor / 否
HY-RS14007 SUFU Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18155 Sufu Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24629 Sufu Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sufu NCBI NCBI:51684
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z