2. Gene
  3. Fermt1 - fermitin family member 1 Gene

Fermt1 - fermitin family member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Kindlin-1; 5830467P10Rik

基因 ID: 241639 | 基因类型: protein coding

关于 Fermt1

功能概要

Enables actin filament binding activity. Involved in several processes, including positive regulation of cell adhesion; regulation of gene expression; and regulation of signal transduction. Located in focal adhesion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study Kindler syndrome. Human ortholog(s) of this gene implicated in Kindler syndrome; telangiectasis; and vesiculobullous skin disease. Orthologous to human FERMT1 (FERM domain containing kindlin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fermt1 基因产物(1)

mRNA Protein Name
NM_198029.2 NP_932146.2 fermitin family homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
16876785 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in basement membrane organization IMP
IMP: 通过突变表型推断
24681597 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
24681597 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
24681597 MGI
involved in negative regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
24681597 MGI
involved in negative regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
24681597 MGI
involved in negative regulation of timing of anagen IMP
IMP: 通过突变表型推断
24681597 MGI
involved in positive regulation of cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
24681597 MGI
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
24681597 MGI
involved in positive regulation of transforming growth factor beta production IMP
IMP: 通过突变表型推断
24681597 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
24681597 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
16876785 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fermitin family homolog 1

unc-112-related protein 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04864 FERMT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21129 Fermt1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27647 Fermt1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fermt1 NCBI NCBI:55612
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