2. Gene
  3. Apoc3 - apolipoprotein C3 Gene

Apoc3 - apolipoprotein C3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ApoC-III; apo-CIII

基因 ID: 24207 | 基因类型: protein coding

关于 Apoc3

功能概要

Predicted to enable high-density lipoprotein particle receptor binding activity; Lipase Inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including Apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human apoC3 (Apolipoprotein C3). [provided by Alliance of Genome Resources, Apr 2022]

Apoc3 基因产物(2)

mRNA Protein Name
NM_001271053.1 NP_001257982.1 apolipoprotein C-III precursor
NM_012501.2 NP_036633.2 apolipoprotein C-III precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
21183731 RGD
involved in lipoprotein transport IDA
IDA: 通过直接分析推断
4020294 RGD
involved in negative regulation of oxidative phosphorylation IDA
IDA: 通过直接分析推断
11177239 RGD
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: 通过突变表型推断
23542898 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
20938723 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
7811230 RGD
involved in response to peptide hormone IDA
IDA: 通过直接分析推断
8429259 RGD
involved in response to triglyceride IEP
IEP: 通过表达模式推断
6698975 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
7811230 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
9888873 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
6419747 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

apolipoprotein C-III

apolipoprotein C-3

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-145727A Volanesorsen sodium Inhibitor 98.51% 否
HY-164740A Plozasiran sodium Inhibitor 97.94% 否
HY-153491 Olezarsen Inhibitor 96.53% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-145727 Volanesorsen Inhibitor 97.97% Phase 3
HY-153491A Olezarsen sodium Inhibitor 96.53% Phase 3
HY-164740 Plozasiran Inhibitor 96.87% Phase 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Apoc3 NCBI NCBI:345
Mus musculus Apoc3 NCBI NCBI:11814
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