2. Gene
  3. Ddc - dopa decarboxylase Gene

Ddc - dopa decarboxylase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: AADC

基因 ID: 24311 | 基因类型: protein coding

关于 Ddc

功能概要

Enables several functions, including amino acid binding activity; aromatic-L-amino-acid decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; phenol-containing compound biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Ddc 基因产物(3)

mRNA Protein Name
NM_001270852.1 NP_001257781.1 aromatic-L-amino-acid decarboxylase isoform a
NM_001270853.1 NP_001257782.1 aromatic-L-amino-acid decarboxylase isoform b
NM_012545.4 NP_036677.1 aromatic-L-amino-acid decarboxylase isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amino acid binding IDA
IDA: 通过直接分析推断
10569946 RGD
enables aromatic-L-amino-acid decarboxylase activity IDA
IDA: 通过直接分析推断
3379830 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16981894 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
19903816 RGD
enables pyridoxal phosphate binding IDA
IDA: 通过直接分析推断
8422386 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aminergic neurotransmitter loading into synaptic vesicle IDA
IDA: 通过直接分析推断
19903816 RGD
involved in cellular response to alkaloid IEP
IEP: 通过表达模式推断
18696327 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
17306206 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18602388 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
12047348 RGD
involved in dopamine biosynthetic process IDA
IDA: 通过直接分析推断
12703659 RGD
involved in isoquinoline alkaloid metabolic process IEP
IEP: 通过表达模式推断
18305432 RGD
involved in phytoalexin metabolic process IEP
IEP: 通过表达模式推断
19185027 RGD
involved in response to pyrethroid IEP
IEP: 通过表达模式推断
19017407 RGD
involved in serotonin biosynthetic process IDA
IDA: 通过直接分析推断
10027744 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
19589383 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
19589383 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
19903816 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aromatic-L-amino-acid decarboxylase

L-Dopa decarboxylase

dopa decarboxylase (aromatic L-amino acid decarboxylase)

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17392 Zalcitabine Inhibitor 99.81% 是
Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139997 DDC-01-163 Degrader 99.05% 否
HY-176489 PROTAC pan-KRAS degrader-1 / 否
HY-151048 JBJ-07-149 Inhibitor 99.09% 否
HY-156179 DDC 2′,3′-O-disulfate Inhibitor / 否
HY-156180 DDC 3′-O-β-D glucuronide / 否
HY-163203 DDC18-8A Inhibitor / 否
HY-163461 4F-DDC Inhibitor / 否
HY-170351 NH2-PEG2-OMs / 否
HY-RS03608 DDC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-170350 Pomalidomide-PEG2-OMs / 否
HY-180325 DDC4002 Inhibitor / 否
HY-RS16935 Ddc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23378 Ddc Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W393396 3'-NH2-ddC / 否
HY-W784611 3'-NH-Tr-2',3'-ddC(Bz)-5'-CE-Phosphoramidite / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ddc NCBI NCBI:1644
Canis familiaris Ddc NCBI NCBI:606852
Macaca fascicularis Ddc NCBI NCBI:102119567
Mus musculus Ddc NCBI NCBI:13195
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