Jak2 - Janus kinase 2 Gene

中文名称：两面神激酶 2

种属: Rattus norvegicus

关于 Jak2

功能概要

该基因编码的蛋白可启动多种功能，包括胰岛素受体底物结合活性；蛋白 C 端结合活性；和信号受体结合活性。参与多个过程，包括细胞表面受体信号通路；蛋白质运输的积极调节；和细胞凋亡过程的调节。位于胞质溶胶中；常染色质；和核仁。活跃于谷氨酸能突触和突触后。用于研究多种疾病，包括高尿酸血症；肝病（多发性）；非酒精性脂肪肝病；视网膜脱离;和血小板增多症。胃肠系统癌症生物标志物（多种）；心脏疾病;肝硬化;和肥胖。该基因的人类直系同源基因与多种疾病有关，包括胃肠系统癌症（多种）；血液系统癌症（多发性）；肝血管疾病（多发性）；炎症性肠病（多发性）；和肺非小细胞癌（多发性）。与人类 JAK2（Janus 激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Insulin Receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein transport; and regulation of apoptotic process. Located in cytosol; euchromatin; and nucleolus. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); non-alcoholic fatty liver disease; retinal detachment; and thrombocytosis. Biomarker of gastrointestinal system Cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]