2. Gene
  3. Nefh - neurofilament heavy chain Gene

Nefh - neurofilament heavy chain Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nfh

基因 ID: 24587 | 基因类型: protein coding

关于 Nefh

功能概要

Enables protein-macromolecule adaptor activity and toxic substance binding activity. A structural constituent of Cytoskeleton. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and ovarian follicle atresia. Located in several cellular components, including dendrite; intermediate filament; and perikaryon. Used to study congenital hypothyroidism. Biomarker of glaucoma; hypothyroidism; phenylketonuria; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefh 基因产物(1)

mRNA Protein Name
NM_012607.2 NP_036739.2 neurofilament heavy polypeptide
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
9388258 RGD
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
11034913 RGD
enables structural constituent of cytoskeleton IDA
IDA: 通过直接分析推断
11034913 RGD
enables toxic substance binding IDA
IDA: 通过直接分析推断
9221839 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon regeneration IDA
IDA: 通过直接分析推断
10646539 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
17401155 RGD
involved in cellular response to hydroperoxide IEP
IEP: 通过表达模式推断
30041238 RGD
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
17401155 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
10439464 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
14620872 RGD
involved in intermediate filament bundle assembly IGI
IGI: 通过遗传相互作用推断
11034913 RGD
involved in neuron projection development IEP
IEP: 通过表达模式推断
1898595 RGD
involved in ovarian follicle atresia IDA
IDA: 通过直接分析推断
22315443 RGD
involved in response to acrylamide IEP
IEP: 通过表达模式推断
17043767 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
24507117 RGD
involved in response to sodium arsenite IDA
IDA: 通过直接分析推断
18674524 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
2108255 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical dendrite IDA
IDA: 通过直接分析推断
27457532 RGD
located in axon IDA
IDA: 通过直接分析推断
7507064 RGD
located in basal proximal dendrite IDA
IDA: 通过直接分析推断
27457532 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
11034913 RGD
located in intermediate filament IDA
IDA: 通过直接分析推断
2230956 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
27457532 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
8544917 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurofilament heavy polypeptide

200 kDa neurofilament protein

NF-H

neurofilament triplet H protein

neurofilament, heavy polypeptide

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09183 NEFH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22249 Nefh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28771 Nefh Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nefh NCBI NCBI:4744
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