2. Gene
  3. Pth - parathyroid hormone Gene

Pth - parathyroid hormone Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Pth1; Pthr1; PTH-(1-84)

基因 ID: 24694 | 基因类型: protein coding

关于 Pth

功能概要

Enables hormone activity; peptide hormone receptor binding activity; and type 1 parathyroid hormone receptor binding activity. Involved in several processes, including Rho protein signal transduction; negative regulation of chondrocyte differentiation; and regulation of bone mineralization. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Located in extracellular space. Used to study several diseases, including chronic kidney disease; hyperphosphatemia; nephrocalcinosis; osteoporosis; and secondary hyperparathyroidism. Biomarker of autosomal dominant hypocalcemia; kidney failure (multiple); osteoporosis; and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone). [provided by Alliance of Genome Resources, Apr 2022]

Pth 基因产物(1)

mRNA Protein Name
NM_017044.1 NP_058740.1 parathyroid hormone precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IMP
IMP: 通过突变表型推断
11604398 RGD
enables parathyroid hormone receptor binding IDA
IDA: 通过直接分析推断
11554727 RGD
enables peptide hormone receptor binding IMP
IMP: 通过突变表型推断
11604398 RGD
enables receptor ligand activity IMP
IMP: 通过突变表型推断
11604398 RGD
enables type 1 parathyroid hormone receptor binding IDA
IDA: 通过直接分析推断
9054374 RGD
enables type 1 parathyroid hormone receptor binding IMP
IMP: 通过突变表型推断
11604398 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rho protein signal transduction IMP
IMP: 通过突变表型推断
15476589 RGD
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9832460 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
11604398 RGD
involved in cell-cell signaling IDA
IDA: 通过直接分析推断
22696456 RGD
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
9832460 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
9832460 RGD
involved in negative regulation of bone mineralization involved in bone maturation IMP
IMP: 通过突变表型推断
11604398 RGD
involved in negative regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
11604398 RGD
involved in positive regulation of bone mineralization IDA
IDA: 通过直接分析推断
15758479 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
8603605 RGD
involved in positive regulation of ossification IDA
IDA: 通过直接分析推断
15758479 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
22708652 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
23376407 RGD
involved in response to fibroblast growth factor IEP
IEP: 通过表达模式推断
23467972 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
23376407 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
22677883 RGD
involved in response to parathyroid hormone IEP
IEP: 通过表达模式推断
9639577 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
22926202 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
22260362 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
23094155 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

parathyroid hormone

hypothalamic parathyroid hormone

parathyrin

相关产品

Approval
生物活性分子 (7)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P0059 Teriparatide Agonist 99.94% 否
HY-P1955A Etelcalcetide hydrochloride Activator 99.80% 否
HY-17613 Evocalcet Activator 99.28% 否
HY-109106A Upacicalcet sodium Agonist 99.91% 否
HY-P1955 Etelcalcetide Activator / 否
HY-109106 Upacicalcet Agonist / 否
HY-P0059A Teriparatide acetate hydrate Agonist / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-100856 PCO371 Agonist 99.67% Phase 1
Pre-clinical Phase
生物活性分子 (55)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112171 γ-L-Glutamyl-L-alanine Modulator 98.0% 否
HY-P1852 TIP 39, Tuberoinfundibular Neuropeptide 99.84% 否
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.32% 否
HY-P2426 (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) Antagonist 99.70% 否
HY-P3075 pTH-Related Protein (1-34) (human,mouse,rat) 98.69% 否
HY-P4823 pTH (1-37) (human) 99.91% 否
HY-P1418A DPC-AJ1951 TFA Agonist 99.38% 否
HY-15103 AH3960 99.92% 否
HY-P4697A pTH (44-68) (human) TFA 99.45% 否
HY-P10078 pTH (39-84) (human) Activator 98.88% 否
HY-P1252 Parathyroid Hormone (1-34), bovine Agonist 99.88% 否
HY-P10909 Canvuparatide Agonist 95.48% 否
HY-P4697 pTH (44-68) (human) / 否
HY-P4715 (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) 99.08% 否
HY-RS11395 PTH1R Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-10003A 1α-Hydroxy-3-epi-vitamin D3 Inhibitor 99.30% 否
HY-109106B (Rac)-Upacicalcet 95.0% 否
HY-113918 SW-106 Antagonist / 否
HY-15106 SB-423557 Antagonist / 否
HY-176943 PTH1R agonist 1 Agonist / 否
HY-176944 PTH1R agonist 2 Agonist / 否
HY-176945 PTH1R agonist 3 Agonist / 否
HY-32351B 3-epi-Calcifediol / 否
HY-P0059S Teriparatide-d10 / 否
HY-P10309 [Nle8,18,Tyr34]-pTH (3-34) amide (human) Ligand / 否
HY-P10313 [Nle8,18,Tyr34]-pTH (3-34) amide (bovine) Inhibitor / 否
HY-P1252A Parathyroid Hormone (1-34), bovine TFA Agonist / 否
HY-P1418 DPC-AJ1951 Agonist / 否
HY-P4690 pTH (13-34) (human) / 否
HY-P4692 pTH (1-44) (human) / 否
HY-P4696 pTH (3-34) (bovine) / 否
HY-P4700 pTH (53-84) (human) / 否
HY-P4701 pTH-Related Protein (1-34) amide (human, mouse, rat) / 否
HY-P4817 Human PTH-(1-31) / 否
HY-P4818 Human PTH-(1-31) amide / 否
HY-P4835 pTH (2-34) (human) / 否
HY-P4849 pTH-Related Protein (1-37) (human, mouse, rat) Activator / 否
HY-P4856 pTH-Related Protein (1-40) (human, mouse, rat) Activator / 否
HY-P4857 pTH-Related Protein (7-34) amide (human, mouse, rat) / 否
HY-RS11394 PTH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11396 PTH2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11397 PTH2R Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11454 PTRH2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W282259 PTH-tyrosine / 否
HY-112171R γ-L-Glutamyl-L-alanine (Standard) Modulator / 否
HY-171446 TAK-075 Antagonist / 否
HY-17613S Evocalcet-d4 Activator / 否
HY-176946 PTH1R agonist 4 Agonist / 否
HY-179356 Octadecyl β-D-glucopyranosiduronic acid Activator / 否
HY-RS16633 Pth Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17667 Pth1r Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20090 Pth2r Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23068 Pth Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24128 Pth1r Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26593 Pth2r Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991361 ABX-10241 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pth NCBI NCBI:5741
Macaca fascicularis Pth NCBI NCBI:102145320
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