2. Gene
  3. Tph1 - tryptophan hydroxylase 1 Gene

Tph1 - tryptophan hydroxylase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Tph

基因 ID: 24848 | 基因类型: protein coding

关于 Tph1

功能概要

Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Located in neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (Tryptophan Hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tph1 基因产物(1)

mRNA Protein Name
NM_001100634.3 NP_001094104.1 tryptophan 5-hydroxylase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables tryptophan 5-monooxygenase activity IDA
IDA: 通过直接分析推断
12354109 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian rhythm IEP
IEP: 通过表达模式推断
18705647 RGD
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
20139991 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
14744469 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tryptophan 5-hydroxylase 1

tryptophan 5-monooxygenase 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-101124 Rodatristat ethyl Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W019599 4-Chloro-L-phenylalanine Inhibitor 98.19% 否
HY-120083 Rodatristat Inhibitor 98.41% 否
HY-157014 TPT-004 Inhibitor 99.90% 否
HY-RS14932 TPH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-156093 TPH1-IN-1 Inhibitor / 否
HY-RS17127 Tph1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23572 Tph1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tph1 NCBI NCBI:7166
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