2. Gene
  3. Nppb - natriuretic peptide B Gene

Nppb - natriuretic peptide B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BNP; Bnf

基因 ID: 25105 | 基因类型: protein coding

关于 Nppb

功能概要

Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). [provided by Alliance of Genome Resources, Apr 2022]

Nppb 基因产物(1)

mRNA Protein Name
NM_031545.1 NP_113733.1 natriuretic peptides B precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
7552344 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell growth involved in cardiac muscle cell development IEP
IEP: 通过表达模式推断
7657802 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
21812548 RGD
involved in heart development IEP
IEP: 通过表达模式推断
8027030 RGD
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
17487460 RGD
involved in negative regulation of cholangiocyte proliferation IDA
IDA: 通过直接分析推断
28416225 RGD
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
19104909 RGD
involved in negative regulation of systemic arterial blood pressure IDA
IDA: 通过直接分析推断
8289999 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: 通过直接分析推断
7552344 RGD
involved in positive regulation of collecting lymphatic vessel constriction IDA
IDA: 通过直接分析推断
23897233 RGD
involved in positive regulation of urine volume IDA
IDA: 通过直接分析推断
8289999 RGD
involved in response to 3-methylcholanthrene IEP
IEP: 通过表达模式推断
19889059 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
17332063 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
17822384 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
22224641 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
33310031 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17673002 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
17919123 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17767048 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
17332063 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16270351 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

natriuretic peptides B

Brain natriuretic factor

brain natriuretic factor prohormone

brain natriuretic peptide

gamma-brain natriuretic peptide

iso-ANP

natriuretic peptide precursor B

natriuretic peptide precursor type B

preproBNP

proBNP

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101012 NPPB Inhibitor 99.78% 否
HY-153392 TYA-018 Inhibitor 99.84% 否
HY-RS09495 NPPB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-180583 GRK5-IN-5 Inhibitor / 否
HY-RS16787 Nppb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23227 Nppb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nppb NCBI NCBI:4879
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