2. Gene
  3. Stat1 - signal transducer and activator of transcription 1 Gene

Stat1 - signal transducer and activator of transcription 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: DD6G4-4

基因 ID: 25124 | 基因类型: protein coding

关于 Stat1

功能概要

Enables CCR5 Chemokine Receptor binding activity; protein Phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; and receptor signaling pathway via JAK-STAT. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including axon; dendrite; and nucleus. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Stat1 基因产物(2)

mRNA Protein Name
NM_001034164.1 NP_001029336.1 signal transducer and activator of transcription 1-alpha/beta isoform beta
NM_032612.3 NP_116001.2 signal transducer and activator of transcription 1-alpha/beta isoform alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR5 chemokine receptor binding IPI
IPI: 通过物理相互作用推断
14674010 RGD
enables DNA binding IDA
IDA: 通过直接分析推断
7519422 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
17084018 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16648019 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blood circulation IMP
IMP: 通过突变表型推断
17361215 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
12191995 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: 通过直接分析推断
19414010 RGD
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
15749807 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19414010 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15948243 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: 通过突变表型推断
22788969 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
17293493 RGD
involved in response to cAMP IDA
IDA: 通过直接分析推断
9144559 RGD
involved in response to cytokine IDA
IDA: 通过直接分析推断
17694433 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
17607690 RGD
involved in response to mechanical stimulus IDA
IDA: 通过直接分析推断
15350851 RGD
involved in response to nutrient IDA
IDA: 通过直接分析推断
15454281 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18031608 RGD
involved in response to peptide hormone IDA
IDA: 通过直接分析推断
15749807 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
17293493 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
14642652 RGD
located in dendrite IDA
IDA: 通过直接分析推断
14642652 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

signal transducer and activator of transcription 1-alpha/beta

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-106981 Orazipone Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115594 Erasin Inhibitor 96.02% 否
HY-173236 STAT4-IN-1 Inhibitor 99.17% 否
HY-170621 STAT1/3-IN-1 Inhibitor 99.23% 否
HY-149209 LL-K8-22 Inhibitor 99.76% 否
HY-122891 SB02024 Activator 99.70% 否
HY-161060 Zharp1-211 Inhibitor 99.15% 否
HY-169360 SD-436 Degrader 98.27% 否
HY-156466 QL-1200186 Inhibitor 99.95% 否
HY-N7595 Microhelenin C Inhibitor 99.55% 否
HY-17663 KMR-206 Activator / 否
HY-119956 Biflorin Inhibitor 99.54% 否
HY-178916 ITA-9 Inhibitor / 否
HY-178915 ITA-5 Inhibitor / 否
HY-180226 Apoptosis inducer 55 Inhibitor / 否
HY-179288 TPST2-IN-1 / 否
HY-178716 PTPN2/1-IN-4 Modulator / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99143 Anti-Mouse NK1.1 Antibody (PK136) Inhibitor 98.57% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat1 NCBI NCBI:6772
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