2. Gene
  3. Tox - thymocyte selection-associated high mobility group box Gene

Tox - thymocyte selection-associated high mobility group box Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 1700007F02Rik

基因 ID: 252838 | 基因类型: protein coding

关于 Tox

功能概要

Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; positive regulation of DNA demethylation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Apr 2022]

Tox 基因产物(3)

mRNA Protein Name
NM_001377078.1 NP_001364007.1 thymocyte selection-associated high mobility group box protein TOX
NM_001377079.1 NP_001364008.1 thymocyte selection-associated high mobility group box protein TOX
NM_145711.5 NP_663757.3 thymocyte selection-associated high mobility group box protein TOX
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
25527292 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment IMP
IMP: 通过突变表型推断
18195075 MGI
involved in CD4-positive, alpha-beta T cell lineage commitment IMP
IMP: 通过突变表型推断
18195075 MGI
involved in CD8-positive, alpha-beta T cell lineage commitment IMP
IMP: 通过突变表型推断
11850626 MGI
involved in NK T cell lineage commitment IMP
IMP: 通过突变表型推断
18195075 MGI
acts upstream of or within Peyer's patch development IMP
IMP: 通过突变表型推断
20818394 MGI
involved in cerebral cortex neuron differentiation IMP
IMP: 通过突变表型推断
25527292 MGI
acts upstream of or within lymph node development IMP
IMP: 通过突变表型推断
20818394 MGI
acts upstream of or within lymphocyte differentiation IMP
IMP: 通过突变表型推断
20818394 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IMP
IMP: 通过突变表型推断
20818394 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
25527292 MGI
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
25527292 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15078895 MGI
involved in regulation of positive thymic T cell selection IMP
IMP: 通过突变表型推断
18195075 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11850626 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thymocyte selection-associated high mobility group box protein TOX

thymocyte selection-associated HMG box

thymus high mobility group box protein TOX

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-176244 KI-TOX-A3 Inhibitor 99.15% 否
HY-D0876 POPSO 95.0% 否
HY-RS14908 TOX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14909 TOX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14910 TOX3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14911 TOX4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17002 Tox Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22349 Tox3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23445 Tox Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28871 Tox3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tox NCBI NCBI:9760
Canis familiaris Tox NCBI NCBI:486964
Macaca fascicularis Tox NCBI NCBI:102136399
Susscrofa domestica Tox NCBI
Rattus norvegicus Tox NCBI NCBI:362481
Macaca mulatta Tox NCBI NCBI:698759
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