2. Gene
  3. Cacna1a - calcium voltage-gated channel subunit alpha1 A Gene

Cacna1a - calcium voltage-gated channel subunit alpha1 A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BccA1; rbA-1; Cav2.1

基因 ID: 25398 | 基因类型: protein coding

关于 Cacna1a

功能概要

Enables Calmodulin binding activity and high voltage-gated Calcium Channel activity. Involved in several processes, including calcium ion import; regulation of voltage-gated Calcium Channel activity; and sensory perception of pain. Located in perikaryon and plasma membrane. Part of voltage-gated Calcium Channel complex. Is integral component of presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1a 基因产物(1)

mRNA Protein Name
NM_012918.5 NP_037050.3 voltage-dependent P/Q-type calcium channel subunit alpha-1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IDA
IDA: 通过直接分析推断
15980432 RGD
enables high voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
17068255 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9303303 RGD
enables voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
9593738 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion import IDA
IDA: 通过直接分析推断
21611731 RGD
involved in calcium ion import IMP
IMP: 通过突变表型推断
15548655 RGD
involved in calcium ion transport IDA
IDA: 通过直接分析推断
9593738 RGD
involved in calcium ion transport IMP
IMP: 通过突变表型推断
14673106 RGD
involved in chemical synaptic transmission IMP
IMP: 通过突变表型推断
14673106 RGD
involved in regulation of voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
17196942 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in calyx of Held IDA
IDA: 通过直接分析推断
25533484 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10964945 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
16736476 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
22683683 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17068255 RGD
part of voltage-gated calcium channel complex IDA
IDA: 通过直接分析推断
16049183 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

voltage-dependent P/Q-type calcium channel subunit alpha-1A

BI

RBA-I

brain calcium channel 1

brain calcium channel I

brain class A

calcium channel alpha 1A

calcium channel, L type, alpha-1 polypeptide

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

calcium channel, voltage-dependent, alpha 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01791 CACNA1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21232 Cacna1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27749 Cacna1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cacna1a NCBI NCBI:773
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