2. Gene
  3. Trh - thyrotropin releasing hormone Gene

Trh - thyrotropin releasing hormone Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: THR; Trf; TRH01; Pro-TRH

基因 ID: 25569 | 基因类型: protein coding

关于 Trh

功能概要

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as Prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]

Trh 基因产物(1)

mRNA Protein Name
NM_013046.3 NP_037178.1 thyrotropin releasing hormone preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables thyrotropin-releasing hormone activity IDA
IDA: 通过直接分析推断
12369739 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in eating behavior IDA
IDA: 通过直接分析推断
16959836 RGD
involved in histamine metabolic process IDA
IDA: 通过直接分析推断
17760865 RGD
involved in negative regulation of feeding behavior IDA
IDA: 通过直接分析推断
17760865 RGD
involved in negative regulation of glutamate secretion IDA
IDA: 通过直接分析推断
16055093 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IDA
IDA: 通过直接分析推断
16990402 RGD
involved in positive regulation of insulin secretion IDA
IDA: 通过直接分析推断
16118471 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
16293347 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
15680480 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
15680480 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15726019 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
16075386 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in secretory granule IDA
IDA: 通过直接分析推断
3930986 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thyrotropin releasing hormone

TSH-releasing factor

pro-thyrotropin-releasing hormone

prothyroliberin

protirelin

thyrotropin-releasing factor

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0596 Taltirelin 99.91% 否
HY-P0002 Protirelin Activator 99.98% 否
HY-P0002A Protirelin acetate Activator 99.87% 是
HY-B0596A Taltirelin acetate 99.38% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-106744 Azetirelin / Phase 3
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y0973 BOP hexafluorophosphate ≥99.0% 否
HY-P3960 (Glu2)-TRH Inhibitor 99.96% 否
HY-P1213 JKC363 Antagonist 99.06% 否
HY-W009673 Boc-Pyr-OH 99.69% 否
HY-P10485 Glp-Asn-Pro-AMC 99.26% 否
HY-107380A PGlu-3-methyl-His-Pro-NH2 TFA 99.69% 否
HY-15113A Y-29794 tosylate Inhibitor 99.86% 否
HY-117178 TA 0910 acid-type Control 99.85% 否
HY-118117 Rovatirelin / 否
HY-15113 Y-29794 Inhibitor / 否
HY-19154 Montirelin / 否
HY-B0596S Taltirelin-13C,d3 / 否
HY-P1213A JKC363 TFA Antagonist / 否
HY-P3962 [Phe2]-TRH / 否
HY-P3964 TRH Precursor Peptide / 否
HY-P3969 Prepro-TRH-(160-169) Agonist / 否
HY-P4367 TRH-AMC / 否
HY-P4584 TRH-βNA / 否
HY-RS15011 TRH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W345393 Trh-gly Agonist / 否
HY-122353 Orotirelin / 否
HY-136800 Posatirelin Inhibitor / 否
HY-RS16699 Trh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23133 Trh Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trh NCBI NCBI:7200
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