GPX6 - glutathione peroxidase 6 Gene

中文名称：谷胱甘肽过氧化物酶 6

种属: Homo sapiens

同用名: GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1

关于 GPX6

功能概要

该基因编码的蛋白质属于谷胱甘肽过氧化物酶家族，其成员催化过氧化氢、有机氢过氧化物和脂质氢过氧化物的还原，从而保护细胞免受氧化损伤。该基因家族的几种同工酶存在于脊椎动物中，它们在细胞位置和底物特异性方面有所不同。已在胚胎和嗅觉上皮细胞中观察到该基因的表达；然而，该基因的确切功能尚不清楚。这种同功酶是人体中的一种硒蛋白，在其活性位点含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。该基因在小鼠和大鼠 (以及其他一些物种) 中的直向同源物包含一个半胱氨酸 (Cys) 残基来代替 Sec 残基，并且它们相应的 mRNA 缺少 SECIS 元件。[RefSeq 提供，2017 年 7 月]

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some Other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]