2. Gene
  3. Hspa4 - heat shock protein family A (Hsp70) member 4 Gene

Hspa4 - heat shock protein family A (Hsp70) member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 A (Hsp70) 成员 4

种属: Rattus norvegicus

同用名: Hsp70; irp94; Hsp110

基因 ID: 266759 | 基因类型: protein coding

关于 Hspa4

Primary_assembly 10: 37,408,025-37,449,001 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 294 orthologues, 13 paralogues and is associated with 18 phenotypes. Biased expression in Kidney (RPKM 486.9), Adrenal (RPKM 469.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性。参与多个过程，包括 DNA 结合活性的负调节；大分子代谢过程的负调控；和血管生成的正调节。位于胞质溶胶中；脂滴;和核。用于研究成人呼吸窘迫综合征和大脑中动脉梗塞。帕金森病和肝脏良性肿瘤的生物标志物。该基因的人类直系同源物与南美锥虫病有关。与人类 HSPA4（热休克蛋白家族 A (HSP70) 成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of macromolecule metabolic process; and positive regulation of angiogenesis. Located in cytosol; lipid droplet; and nucleus. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (HSP70) member 4). [provided by Alliance of Genome Resources, Apr 2022]

Hspa4 基因产物(1)

mRNA Protein Name
NM_153629.1 NP_705893.1 heat shock 70 kDa protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17473852 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17473852 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
21561597 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in kidney development IEP
IEP: 通过表达模式推断
21938673 RGD
involved in negative regulation of apoptotic process IEP
IEP: 通过表达模式推断
21857080 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
17473852 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
17473852 RGD
involved in neuron apoptotic process IMP
IMP: 通过突变表型推断
17473852 RGD
involved in positive regulation of angiogenesis IEP
IEP: 通过表达模式推断
22098710 RGD
involved in regulation of microglial cell activation IMP
IMP: 通过突变表型推断
17473852 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lipid droplet IDA
IDA: 通过直接分析推断
17175194 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hspa4 蛋白结构

HSPA4_NBD

HSPA4_NBD: cd11737 (1 - 383)

PTZ00121

PTZ00121: cl31754 (498 - 742)

  • 0
  • 200
  • 400
  • 600
  • 840 a.a.
蛋白主名 其他名称

heat shock 70 kDa protein 4

heat shock protein 4

heat shock protein family A member 4

ischemia responsive 94 kDa protein

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06428 HSPA4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06429 Hspa4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06430 Hspa4 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06431 HSPA4L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21867 Hspa4l Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hspa4 NCBI NCBI:3308
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