2. Gene
  3. Pkp2 - plakophilin 2 Gene

Pkp2 - plakophilin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 287925 | 基因类型: protein coding

关于 Pkp2

功能概要

Predicted to enable several functions, including alpha-catenin binding activity; intermediate filament binding activity; and protein kinase C binding activity. Involved in several processes, including cell-cell junction organization; lipid homeostasis; and regulation of bicellular tight junction assembly. Located in adherens junction and intercalated disc. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pkp2 基因产物(1)

mRNA Protein Name
NM_001100499.1 NP_001093969.1 plakophilin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21062920 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adherens junction maintenance IMP
IMP: 通过突变表型推断
18261826 RGD
involved in cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
19661460 RGD
involved in gap junction assembly IMP
IMP: 通过突变表型推断
17673670 RGD
involved in lipid homeostasis IMP
IMP: 通过突变表型推断
21985446 RGD
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
21985446 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21985446 RGD
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
21617128 RGD
involved in regulation of bicellular tight junction assembly IMP
IMP: 通过突变表型推断
19509333 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
16406610 RGD
located in cell junction IDA
IDA: 通过直接分析推断
26858265 RGD
located in desmosome IDA
IDA: 通过直接分析推断
21617128 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
19661460 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

plakophilin-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10612 PKP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20326 Pkp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26834 Pkp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pkp2 NCBI NCBI:5318
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