1. Gene
  2. GRIK5 - glutamate ionotropic receptor kainate type subunit 5 Gene

GRIK5 - glutamate ionotropic receptor kainate type subunit 5 Gene

中文名称:谷氨酸离子型受体红藻氨酸亚基 5

种属: Homo sapiens

同用名: KA2; EAA2; GRIK2; GluK5

基因 ID: 2901 | 基因类型: protein coding

关于 GRIK5

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,998,324-42,070,206 (from NCBI)

This gene has 6 transcripts (splice variants), 301 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues.

功能概要

该基因编码一种属于谷氨酸门控离子通道家族的蛋白质。谷氨酸通过激活配体门控离子通道和 G 蛋白偶联膜受体发挥中枢神经系统中主要兴奋性神经递质的作用。由该基因编码的蛋白质与相关基因家族成员编码的亚基形成功能性异聚红藻氨酸偏好离子通道。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 7 月]

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GRIK5 基因产物(2)

mRNA Protein Name
NM_001301030.2 NP_001287959.1 glutamate receptor ionotropic, kainate 5 isoform 1 precursor
NM_002088.5 NP_002079.3 glutamate receptor ionotropic, kainate 5 isoform 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
14511640 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GRIK5 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (42 - 379)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (426 - 490)

Lig_chan

Lig_chan: Ligand-gated ion channel (545 - 815)

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  • 980 a.a.
蛋白主名 其他名称

glutamate receptor ionotropic, kainate 5

excitatory amino acid receptor 2

关联疾病

疾病名称 别名
Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GRIK5 VGNC VGNC:41490
Macaca mulatta GRIK5 VGNC VGNC:73280
Felis catus GRIK5 VGNC VGNC:67470
Rattus norvegicus GRIK5 RGD RGD:2735
Bos taurus GRIK5 VGNC VGNC:57048
Mus musculus GRIK5 MGD MGI:95818