BRD2 - bromodomain containing 2 Gene

中文名称：含溴结构域 2

种属: Rattus norvegicus

同用名: Ring3

关于 BRD2

功能概要

预测该基因编码的蛋白可启动赖氨酸-乙酰化组蛋白结合活性；核小体组蛋白结合活性；和蛋白丝氨酸/苏氨酸激酶活性。预计参与核小体组装；蛋白质磷酸化； RNA 聚合酶 II 对转录的调控。预测位于核斑点。预计在染色质和细胞核中有活性。该基因的人类直系同源物与 B 细胞淋巴瘤有关； B-淋巴细胞白血病/淋巴瘤；青少年肌阵挛性癫痫；和光敏性疾病。与人类 BRD2 同源（含溴结构域 2）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in nucleosome assembly; protein phosphorylation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]