2. Gene
  3. Shh - sonic hedgehog signaling molecule Gene

Shh - sonic hedgehog signaling molecule Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ShhNC

基因 ID: 29499 | 基因类型: protein coding

关于 Shh

功能概要

Predicted to enable several functions, including laminin-1 binding activity; metal ion binding activity; and patched binding activity. Involved in several processes, including animal organ development; negative regulation of cell death; and nervous system development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including membrane raft; neuronal cell body; and synaptic vesicle. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Shh 基因产物(1)

mRNA Protein Name
NM_017221.1 NP_058917.1 sonic hedgehog protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19139721 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in commissural neuron axon guidance IMP
IMP: 通过突变表型推断
19946319 RGD
involved in digestive tract mesoderm development IDA
IDA: 通过直接分析推断
9368764 RGD
involved in epithelial tube branching involved in lung morphogenesis IEP
IEP: 通过表达模式推断
8769111 RGD
involved in fungiform papilla development IMP
IMP: 通过突变表型推断
15581865 RGD
involved in fungiform papilla formation IMP
IMP: 通过突变表型推断
15581865 RGD
involved in fungiform papilla morphogenesis IMP
IMP: 通过突变表型推断
15581865 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
22790641 RGD
involved in male genitalia morphogenesis IMP
IMP: 通过突变表型推断
12533405 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16988214 RGD
involved in neural tube formation IMP
IMP: 通过突变表型推断
8124714 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
9236238 RGD
involved in positive regulation of endothelial cell chemotaxis IDA
IDA: 通过直接分析推断
20052412 RGD
involved in positive regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
12469128 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
8124714 RGD
involved in positive regulation of neurotrophin production IMP
IMP: 通过突变表型推断
23237228 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IDA
IDA: 通过直接分析推断
12237843 RGD
involved in positive regulation of penile erection IMP
IMP: 通过突变表型推断
12533405 RGD
involved in positive regulation of photoreceptor cell differentiation IDA
IDA: 通过直接分析推断
9236238 RGD
involved in positive regulation of sprouting angiogenesis IDA
IDA: 通过直接分析推断
20052412 RGD
involved in prostate gland development IEP
IEP: 通过表达模式推断
15328011 RGD
involved in regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12417650 RGD
involved in regulation of epithelial cell differentiation IEP
IEP: 通过表达模式推断
14651923 RGD
involved in response to axon injury IMP
IMP: 通过突变表型推断
15356205 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
15328011 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
19139721 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
18228117 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
10633866 RGD
acts upstream of or within spinal cord dorsal/ventral patterning IDA
IDA: 通过直接分析推断
9230312 RGD
involved in telencephalon regionalization IMP
IMP: 通过突变表型推断
9811591 RGD
involved in tongue development IMP
IMP: 通过突变表型推断
15581865 RGD
involved in tongue morphogenesis IMP
IMP: 通过突变表型推断
15581865 RGD
acts upstream of or within ventral spinal cord interneuron specification IDA
IDA: 通过直接分析推断
9230312 RGD
involved in zona limitans intrathalamica formation IDA
IDA: 通过直接分析推断
25281935 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
21182949 RGD
located in dendrite IDA
IDA: 通过直接分析推断
21182949 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
19139721 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22446553 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
22446553 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21182949 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
22446553 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
22446553 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
28262835 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sonic hedgehog protein

shh unprocessed N-terminal signaling and C-terminal autoprocessing domains

sonic hedgehog homolog

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0508 Ornidazole Inhibitor 99.49% 否
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100224 SANT-1 99.87% 否
HY-100515 Robotnikinin Inhibitor 98.98% 否
HY-108439 Neurodazine Activator 99.0% 否
HY-158059 DS-1-38 Inhibitor 99.60% 否
HY-144881 (S)-HH2853 Inhibitor / 否
HY-123781A RUSKI-201 dihydrochloride Inhibitor 98.20% 否
HY-145387 MRT-81 Antagonist 99.85% 否
HY-P10875 HL2-m5 Inhibitor 98.06% 否
HY-116455 BRD-9526 / 否
HY-147743 SMO-IN-1 Inhibitor / 否
HY-147744 AZD7254 Inhibitor / 否
HY-B0508S Ornidazole-d5 Inhibitor / 否
HY-B0508S1 Ornidazole-13C2,15N2 Inhibitor / 否
HY-RS12865 SHH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-120664 BRD50837 Inhibitor / 否
HY-123781 RUSKI-201 Inhibitor / 否
HY-164500 MC3629 Inhibitor / 否
HY-N18954 Heparin disaccharide III-S (trisodium) Inhibitor / 否
HY-RS16599 Shh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23033 Shh Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shh NCBI NCBI:6469
Mus musculus Shh NCBI NCBI:20423
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