Elane - elastase, neutrophil expressed Gene

种属: Rattus norvegicus

同用名: Ela2

关于 Elane

功能概要

Predicted to enable several functions, including heparin binding activity; protease binding activity; and serine-type endopeptidase activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and secretory granule. Predicted to be part of transcription repressor complex. Predicted to be active in extracellular space. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (Elastase, neutrophil expressed). [provided by Alliance of Genome Resources, Apr 2022]