MDFIC - MyoD family inhibitor domain containing Gene

中文名称：含 MyoD 家族抑制剂结构域

种属: Homo sapiens

同用名: HIC; MDFIC1; LMPHM12

基因 ID: 29969 | 基因类型: protein coding

关于 MDFIC

Cytogenetic location: 7q31.1-q31.2 Genomic coordinates (GRCh38): 7:114,922,094-115,019,917 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 25.2), spleen (RPKM 14.3) and 23 other tissues.

功能概要

该基因产物是一个蛋白质家族的成员，其特征是具有特定的富含半胱氨酸的 C 末端结构域，该结构域参与病毒基因组表达的转录调控。来自上游非 AUG (GUG) 和框内下游 AUG 密码子的替代翻译起始，导致产生两种亚型，分别是 p40 和 p32，它们具有不同的亚细胞定位； p32 主要存在于细胞质中，而 p40 靶向核仁。两种亚型都具有转录调节活性，这归因于富含半胱氨酸的 C 末端结构域。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

MDFIC 基因产物(3)

mRNA	Protein	Name
NM_001166345.3	NP_001159817.1	myoD family inhibitor domain-containing protein isoform p32
NM_001166346.1	NP_001159818.3	myoD family inhibitor domain-containing protein isoform c
NM_199072.5	NP_951038.1	myoD family inhibitor domain-containing protein isoform p40

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	12192039	GOA
enables Tat protein binding	IDA IDA: 通过直接分析推断	12944466	GOA
enables cyclin binding	IPI IPI: 通过物理相互作用推断	12944466	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12192039	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12944466	GOA
involved in positive regulation of viral transcription	IDA IDA: 通过直接分析推断	10671520	GOA
involved in regulation of JNK cascade	IDA IDA: 通过直接分析推断	12192039	GOA
involved in regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	12192039	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10671520	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	10671520	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10671520	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MDFIC 蛋白结构

MDFI

0
100
200
246 a.a.

蛋白主名

其他名称

myoD family inhibitor domain-containing protein

I-mfa domain-containing protein

关联疾病

疾病名称

别名

Lymphatic Malformation 12

Central Conducting Lymphatic Anomaly	LMPHM12
Ccla	Lymphatic Malformation-7
Doid:0081030

Hypogonadotropic Hypogonadism 16 With Or Without Anosmia

HH16	Hypogonadism, Hypogonadotropic, Type 16 With/Without Anosmia

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Cleft Palate, Cardiac Defects, And Mental Retardation

Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies	CPCMR
Cleft Palate, Cardiac Defects, And Intellectual Disabillity	Cleft Palate, Cardiac Defects, And Intellectual Disability
Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies

Leukodystrophy, Hypomyelinating, 5

Hypomyelination And Congenital Cataract	HLD5
Hypomyelination-Congenital Cataract Syndrome	Hypomyelinating Leukodystrophy 5
Hcc	Hypomyelination And Congenital Cataract: Hcc
Hypomyelination - Congenital Cataract	Hypomyelination With Congenital Cataract

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08257	MDFIC Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MDFIC	VGNC	VGNC:31330
Canis familiaris	MDFIC	VGNC	VGNC:43100
Mus musculus	MDFIC	MGD	MGI:104611
Felis catus	MDFIC	VGNC	VGNC:102635
Macaca mulatta	MDFIC	VGNC	VGNC:74608
Rattus norvegicus	MDFIC	RGD	RGD:1309532

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MDFIC - MyoD family inhibitor domain containing Gene

关于 MDFIC

功能概要

MDFIC 基因产物(3)

MDFIC 蛋白结构

关联疾病

直系同源

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MDFIC - MyoD family inhibitor domain containing Gene

关于 MDFIC

功能概要

MDFIC 基因产物(3)

MDFIC 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

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T

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