Mttp - microsomal triglyceride transfer protein Gene

中文名称：微粒体甘油三酯转移蛋白

种属: Rattus norvegicus

同用名: MTP

关于 Mttp

功能概要

该基因编码的蛋白可启动载脂蛋白结合活性和脂质转移活性。参与多个过程，包括胆固醇稳态；脂蛋白代谢过程；和对钙离子的反应。位于几种细胞成分中，包括基底外侧质膜；细胞投射膜；和粗面内质网。家族性高脂血症的生物标志物。该基因的人类直系同源物与多种疾病有关，包括腹部肥胖代谢综合征 1；无β脂蛋白血症；家族性高胆固醇血症；高胰岛素血症;和肥胖。与人类 MTTP（微粒体甘油三酯转移蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including Cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and rough endoplasmic reticulum. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]