2. Gene
  3. Itga4 - integrin subunit alpha 4 Gene

Itga4 - integrin subunit alpha 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 311144 | 基因类型: protein coding

关于 Itga4

功能概要

Enables cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and regulation of leukocyte migration. Located in several cellular components, including extracellular exosome; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 基因产物(1)

mRNA Protein Name
NM_001107737.1 NP_001101207.1 integrin alpha-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables antigen binding IPI
IPI: 通过物理相互作用推断
20124479 RGD
enables cell adhesion molecule binding IMP
IMP: 通过突变表型推断
9773789 RGD
enables fibronectin binding IMP
IMP: 通过突变表型推断
9773789 RGD
enables protein antigen binding IPI
IPI: 通过物理相互作用推断
20124479 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20124479 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonogenesis involved in innervation IMP
IMP: 通过突变表型推断
16181811 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
12046991 RGD
involved in clathrin-dependent extracellular exosome endocytosis IMP
IMP: 通过突变表型推断
20124479 RGD
involved in diapedesis IMP
IMP: 通过突变表型推断
8550078 RGD
involved in import into cell IMP
IMP: 通过突变表型推断
20124479 RGD
involved in neuron projection extension IMP
IMP: 通过突变表型推断
16181811 RGD
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
8580084 RGD
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
7680140 RGD
involved in positive regulation of leukocyte migration IMP
IMP: 通过突变表型推断
8550078 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: 通过突变表型推断
9394821 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
9773789 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12486170 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12486170 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin alpha-4

integrin, alpha 4

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99184 Abrilumab 98.35% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06951 ITGA4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17832 Itga4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24300 Itga4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itga4 NCBI NCBI:3676
Macaca fascicularis Itga4 NCBI NCBI:102128433
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