2. Gene
  3. Ercc6 - excision repair cross-complementing rodent repair deficiency, complementation group 6 Gene

Ercc6 - excision repair cross-complementing rodent repair deficiency, complementation group 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CSB; 4732403I04; C130058G22Rik

基因 ID: 319955 | 基因类型: protein coding

关于 Ercc6

功能概要

Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including intracellular signal transduction; nucleic acid metabolic process; and photoreceptor cell maintenance. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in genitourinary system. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]

Ercc6 基因产物(1)

mRNA Protein Name
NM_001081221.2 NP_001074690.1 DNA excision repair protein ERCC-6
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
11408355 MGI
acts upstream of or within DNA repair IGI
IGI: 通过遗传相互作用推断
12447686 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
10806208 MGI
acts upstream of or within JNK cascade IMP
IMP: 通过突变表型推断
16319174 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
11005836 MGI
acts upstream of or within multicellular organism growth IGI
IGI: 通过遗传相互作用推断
22323595 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: 通过突变表型推断
17145777 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
22323595 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IMP
IMP: 通过突变表型推断
22323595 MGI
acts upstream of or within pyrimidine dimer repair IMP
IMP: 通过突变表型推断
9150142 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
10843671 MGI
acts upstream of or within response to UV-B IMP
IMP: 通过突变表型推断
10850428 MGI
acts upstream of or within response to X-ray IMP
IMP: 通过突变表型推断
15979950 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
15340056 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
12509265 MGI
acts upstream of or within response to superoxide IMP
IMP: 通过突变表型推断
15340056 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
11408355 MGI
acts upstream of or within transcription elongation by RNA polymerase I IMP
IMP: 通过突变表型推断
23562818 MGI
acts upstream of or within transcription-coupled nucleotide-excision repair IMP
IMP: 通过突变表型推断
9150142 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA excision repair protein ERCC-6

ATP-dependent helicase ERCC6

CS group B correcting

cockayne syndrome protein CSB

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04483 ERCC6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04484 ERCC6L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04485 ERCC6L2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20400 Ercc6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21852 Ercc6l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26909 Ercc6 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28369 Ercc6l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ercc6 NCBI NCBI:2074
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