2. Gene
  3. Als2 - alsin Rho guanine nucleotide exchange factor ALS2 Gene

Als2 - alsin Rho guanine nucleotide exchange factor ALS2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 363235 | 基因类型: protein coding

关于 Als2

功能概要

Predicted to enable enzyme activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in several processes, including Rac protein signal transduction; axonogenesis; and in utero embryonic development. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]

Als2 基因产物(1)

mRNA Protein Name
NM_001013413.1 NP_001013431.1 alsin
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rac protein signal transduction IDA
IDA: 通过直接分析推断
16802292 RGD
involved in axonogenesis IMP
IMP: 通过突变表型推断
16802292 RGD
involved in in utero embryonic development IEP
IEP: 通过表达模式推断
16049005 RGD
involved in regulation of endosome size IMP
IMP: 通过突变表型推断
16802292 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15033976 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
15033976 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15033976 RGD
located in growth cone IDA
IDA: 通过直接分析推断
16049005 RGD
located in membrane IDA
IDA: 通过直接分析推断
15033976 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15033976 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alsin

ALS2, alsin Rho guanine nucleotide exchange factor

amyotrophic lateral sclerosis 2 (juvenile)

amyotrophic lateral sclerosis 2 protein homolog

amyotrophic lateral sclerosis protein 2 homolog

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00634 ALS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00635 ALS2CL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W611371A FP802 dihydrochloride Inhibitor 99.84% 否
HY-RS17942 Als2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24413 Als2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Als2 NCBI NCBI:57679
Macaca fascicularis Als2 NCBI NCBI:101925534
Mus musculus Als2 NCBI NCBI:74018
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