ITIH1 - inter-alpha-trypsin inhibitor heavy chain 1 Gene

中文名称：α-胰蛋白酶抑制因子重链 1

种属: Homo sapiens

同用名: H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1

关于 ITIH1

功能概要

该基因编码 inter-alpha-胰蛋白酶抑制剂蛋白家族的成员。可变剪接导致多种转录本变体，其中至少一种编码前原蛋白，该前原蛋白经过蛋白水解处理以生成 inter-alpha-胰蛋白酶抑制剂复合物的重链，该复合物由肝细胞分泌到血液中。重链还与乙酰透明质酸相互作用，这种相互作用可能在排卵和受精中发挥作用，并与多种炎症性疾病有关。该基因存在于 3 号染色体上的基因簇中。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]