Kif14 - kinesin family member 14 Gene

中文名称：驱动蛋白家族成员 14

种属: Mus musculus

同用名: D1Ertd367e; E130203M01

关于 Kif14

功能概要

该基因编码的蛋白可启动 ATP 绑定活动；微管结合活性；和加端定向微管运动活动。参与多个过程，包括大脑发育；神经元凋亡过程的负调控；和髓鞘形成的调节。预测位于弗莱明体内；胞质溶胶；和主轴中间区。预计是驱动蛋白复合物的一部分。预计在微管中活跃。预测与质膜共定位。在视网膜中表达。该基因的人类直系同源物与梅克尔综合征和原发性常染色体隐性小头畸形有关。与人类 KIF14（驱动蛋白家族成员 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in Flemming body; cytosol; and spindle midzone. Predicted to be part of Kinesin complex. Predicted to be active in microtubule. Predicted to colocalize with plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (Kinesin family member 14). [provided by Alliance of Genome Resources, Apr 2022]