2. Gene
  3. NOSIP - nitric oxide synthase interacting protein Gene

NOSIP - nitric oxide synthase interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：一氧化氮合酶相互作用蛋白

种属: Homo sapiens

同用名: CGI-25

基因 ID: 51070 | 基因类型: protein coding

关于 NOSIP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,555,468-49,580,556 (from NCBI)

This gene has 16 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质可以调节一氧化氮合酶 (内皮和神经元) 的活性和定位，从而调节一氧化氮的产生。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

NOSIP 基因产物(3)

mRNA Protein Name
NM_001270960.2 NP_001257889.1 nitric oxide synthase-interacting protein isoform 1
NM_001363649.2 NP_001350578.1 nitric oxide synthase-interacting protein isoform 2
NM_015953.5 NP_057037.1 nitric oxide synthase-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular sequestering activity IPI
IPI: 通过物理相互作用推断
15548660 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11149895 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of catalytic activity IDA
IDA: 通过直接分析推断
11149895 GOA
involved in negative regulation of nitric-oxide synthase activity IDA
IDA: 通过直接分析推断
11149895 GOA
involved in regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
15548660 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15548660 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15548660 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nitric oxide synthase-interacting protein

E3 ubiquitin-protein ligase NOSIP

关联疾病

疾病名称 别名
Lipodystrophy, Congenital Generalized, Type 3

Congenital Generalized Lipodystrophy Type 3

CGL3

Bscl3

Berardinelli-Seip Congenital Lipodystrophy Type 3

Berardinelli-Seip Congenital Lipodystrophy, Type 3

Lipodystrophy, Berardinelli-Seip Congenital, Type 3

Type 3 Berardinelli-Seip Congenital Lipodystrophy

Congenital Generalized Lipodystrophy 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09443 NOSIP Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NOSIP MGD MGI:1913644
Macaca mulatta NOSIP VGNC VGNC:75207
Canis familiaris NOSIP VGNC VGNC:53744
Rattus norvegicus NOSIP RGD RGD:1309992
Bos taurus NOSIP VGNC VGNC:32175
Felis catus NOSIP VGNC VGNC:63861
Others NOSIP NCBI
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