2. Gene
  3. GULP1 - GULP PTB domain containing engulfment adaptor 1 Gene

GULP1 - GULP PTB domain containing engulfment adaptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 GULP PTB 域的吞没适配因子 1

种属: Homo sapiens

同用名: CED6; GULP; CED-6

基因 ID: 51454 | 基因类型: protein coding

关于 GULP1

Cytogenetic location: 2q32.1-q32.2 Genomic coordinates (GRCh38): 2:188,291,874-188,595,926 (from NCBI)

This gene has 20 transcripts (splice variants), 235 orthologues and 11 paralogues. Broad expression in endometrium (RPKM 8.3), prostate (RPKM 7.5) and 22 other tissues.

功能概要

该基因编码的蛋白质是吞噬细胞吞噬凋亡细胞所必需的衔接蛋白。已经发现该基因的几种转录变体，一些蛋白质编码和一些被认为不是蛋白质编码。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GULP1 基因产物(32)

mRNA Protein Name
NM_001252668.2 NP_001239597.1 PTB domain-containing engulfment adapter protein 1 isoform b
NM_001252669.2 NP_001239598.1 PTB domain-containing engulfment adapter protein 1 isoform c
NM_001375925.1 NP_001362854.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375926.1 NP_001362855.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375927.1 NP_001362856.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375928.1 NP_001362857.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375929.1 NP_001362858.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375930.1 NP_001362859.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375931.1 NP_001362860.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375932.1 NP_001362861.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375933.1 NP_001362862.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375934.1 NP_001362863.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375935.1 NP_001362864.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375936.1 NP_001362865.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375937.1 NP_001362866.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375938.1 NP_001362867.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375939.1 NP_001362868.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375940.1 NP_001362869.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375941.1 NP_001362870.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375942.1 NP_001362871.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375943.1 NP_001362872.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375944.1 NP_001362873.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375945.1 NP_001362874.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375946.1 NP_001362875.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375947.1 NP_001362876.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375948.1 NP_001362877.1 PTB domain-containing engulfment adapter protein 1 isoform g
NM_001375949.1 NP_001362878.1 PTB domain-containing engulfment adapter protein 1 isoform g
NM_001375950.1 NP_001362879.1 PTB domain-containing engulfment adapter protein 1 isoform h
NM_001375951.1 NP_001362880.1 PTB domain-containing engulfment adapter protein 1 isoform i
NM_001375952.1 NP_001362881.1 PTB domain-containing engulfment adapter protein 1 isoform j
NM_001375953.1 NP_001362882.1 PTB domain-containing engulfment adapter protein 1 isoform k
NM_016315.4 NP_057399.1 PTB domain-containing engulfment adapter protein 1 isoform a
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within phagocytosis, engulfment IDA
IDA: 通过直接分析推断
11729193 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GULP1 蛋白结构

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (27 - 154)

  • 0
  • 100
  • 200
  • 304 a.a.
蛋白主名 其他名称

PTB domain-containing engulfment adapter protein 1

GULP, engulfment adaptor PTB domain containing 1

关联疾病

疾病名称 别名
Thyroid Dyshormonogenesis 4

Deiodinase Deficiency

TDH4

Iodotyrosine Dehalogenase Deficiency

Thyroid Hormonogenesis, Genetic Defect In, 4

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4

Genetic Defect In Thyroid Hormonogenesis 4

Chdh4

Congenital Hypothyroidism Due To Dyshormonogenesis Type 4

Genetic Defect In Thyroid Hormonogenesis Type 4
Niemann-Pick Disease, Type B

Niemann-Pick Disease Type B

Acid Sphingomyelinase Deficiency, Visceral Type

Asmd, Visceral Type

Niemann Pick Disease Type B

Chronic Visceral Acid Sphingomyelinase Deficiency

Chronic Visceral Asmd

Npd-B

Niemann-Pick Disease B

NPDB

Niemann-Pick Disease Adult Non-Neuronopathic Form

Niemann-Pick Disease Intermediate With Visceral Involvement And Rapid Progression

Niemann-Pick Disease Type E

Niemann-Pick Disease Type F

Niemann-Pick Disease Type I

Niemann-Pick Disease Visceral Form

Npb

Sphingomyelinase Deficiency

Sphingomyelin Lipidosis

Niemann-Picks Disease Type B

Niemann-Pick Disease, Type E

Niemann-Pick Diseases

Niemann-Pick Disease, Type A
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05926 GULP1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GULP1 VGNC VGNC:62741
Mus musculus GULP1 MGD MGI:1920407
Bos taurus GULP1 VGNC VGNC:50050
Canis familiaris GULP1 VGNC VGNC:53097
Macaca mulatta GULP1 VGNC VGNC:73193
Rattus norvegicus GULP1 RGD RGD:1306380
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