PALS2 - protein associated with LIN7 2, MAGUK p55 family member Gene

中文名称：与 LIN7 2 相关的蛋白质，MAGUK p55 家族成员

种属: Homo sapiens

同用名: MPP6; VAM1; p55T; VAM-1

关于 PALS2

功能概要

外周膜相关鸟苷酸激酶 (MAGUK) 家族成员通过形成包含不同组的跨膜、细胞骨架和细胞质信号转导蛋白的多蛋白复合物，在肿瘤抑制和受体聚集中发挥作用。所有 MAGUK 都包含一个 PDZ-SH3-GUK 核心并分为 4 个亚家族，类 DLG (参见 DLG1；MIM 601014) ，类 ZO1 (参见 TJP1；MIM 601009) ，类 p55 (参见 MPP1；MIM 305360) ，和 LIN2-like (参见 CASK；MIM 300172) ，基于它们的大小和附加域的存在。 MPP6 是 p55 样 MAGUK 亚家族的成员 (Tseng 等人，2001 [PubMed 11311936]) 。[OMIM 提供，2008 年 3 月]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]