1. Gene
  2. PFDN2 - prefoldin subunit 2 Gene

PFDN2 - prefoldin subunit 2 Gene

中文名称:前折叠蛋白亚基 2

种属: Homo sapiens

同用名: PFD2

基因 ID: 5202 | 基因类型: protein coding

关于 PFDN2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,100,561-161,118,037 (from NCBI)

This gene has 2 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in fat (RPKM 33.7), brain (RPKM 30.3) and 25 other tissues.

功能概要

该基因编码 prefoldin beta 亚基家族的成员。编码的蛋白质是 prefoldin 的六个亚基之一,prefoldin 是一种分子伴侣复合物,可结合并稳定新合成的多肽,从而使它们能够正确折叠。该复合体由两个 alpha 和四个 beta 亚基组成,形成一个带有六个突出的卷曲螺旋的双 beta 桶组件。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

PFDN2 基因产物(1)

mRNA Protein Name
NM_012394.4 NP_036526.2 prefoldin subunit 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IDA
IDA: 通过直接分析推断
23614719 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15923622 GOA
enables protein folding chaperone IPI
IPI: 通过物理相互作用推断
16876117 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
30955883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of amyloid fibril formation IDA
IDA: 通过直接分析推断
23614719 GOA
involved in positive regulation of cytoskeleton organization IDA
IDA: 通过直接分析推断
16876117 GOA
involved in protein folding IDA
IDA: 通过直接分析推断
30955883 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: 通过物理相互作用推断
31738558 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16876117 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
17936702 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16876117 GOA
part of prefoldin complex IDA
IDA: 通过直接分析推断
23614719 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PFDN2 蛋白结构

Prefoldin_2

Prefoldin_2: Prefoldin subunit (24 - 128)

  • 0
  • 100
  • 154 a.a.
蛋白主名 其他名称

prefoldin subunit 2

prefoldin 2

PFDN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PFDN2 Q9UHV9 UQCRC1 Homo sapiens P31930 32814053
种属内
PFDN2 Q9UHV9 UQCRC1 Homo sapiens P31930 32814053
种属内
PFDN2 Q9UHV9 UQCRC1 Homo sapiens P31930 32814053
种属内
PFDN2 Q9UHV9 ZNF726 Homo sapiens A6NNF4-2 32296183
种属内
PFDN2 Q9UHV9 ZNF726 Homo sapiens A6NNF4-2 32296183
种属内
PFDN2 Q9UHV9 POLR3A Homo sapiens O14802 33961781
种属内
PFDN2 Q9UHV9 PDRG1 Homo sapiens Q9NUG6 28514442
种属内
PFDN2 Q9UHV9 PDRG1 Homo sapiens Q9NUG6 25036637
种属内
PFDN2 Q9UHV9 PDRG1 Homo sapiens Q9NUG6 33961781
种属内
PFDN2 Q9UHV9 PFDN1 Homo sapiens O60925 28514442
种属内
PFDN2 Q9UHV9 PFDN1 Homo sapiens O60925 33961781
种属内
PFDN2 Q9UHV9 PFDN1 Homo sapiens O60925
Y2H
16876117
种属内
PFDN2 Q9UHV9 RPAP3 Homo sapiens Q9H6T3 25036637
种属内
PFDN2 Q9UHV9 URI1 Homo sapiens O94763 25036637
种属内
PFDN2 Q9UHV9 URI1 Homo sapiens O94763 33961781
种属内
PFDN2 Q9UHV9 PFDN5 Homo sapiens Q99471 25036637
种属内
PFDN2 Q9UHV9 PFDN5 Homo sapiens Q99471 33961781
种属内
PFDN2 Q9UHV9 PFDN5 Homo sapiens Q99471 32296183
种属内
PFDN2 Q9UHV9 PFDN5 Homo sapiens Q99471 28514442
种属内
PFDN2 Q9UHV9 PFDN5 Homo sapiens Q99471 32296183
种属内
PFDN2 Q9UHV9 UXT Homo sapiens Q9UBK9 33961781
种属内
PFDN2 Q9UHV9 UXT Homo sapiens Q9UBK9 28514442
种属内
PFDN2 Q9UHV9 VBP1 Homo sapiens P61758 33961781
种属内
PFDN2 Q9UHV9 VBP1 Homo sapiens P61758 32296183
种属内
PFDN2 Q9UHV9 VBP1 Homo sapiens P61758 32296183
种属内
PFDN2 Q9UHV9 VBP1 Homo sapiens P61758 28514442
种属间
PFDN2 Q9UHV9 f_hcv77 Hepatitis C virus P0C045 16876117
种属间
PFDN2 Q9UHV9 f_hcv77 Hepatitis C virus P0C045
Y2H
16876117
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PFDN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71197 PFDN2 Protein, Human (His) Q9UHV9 (M1-S154) ≥ 95%, as determined by reducing SDS-PAGE.

关联疾病

疾病名称 别名
Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4

SRTD4

Atd4

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 4

Variegate Porphyria

Porphyria Variegata

Protoporphyrinogen Oxidase Deficiency

VP

Ppox Deficiency

Porphyria, South African Type

Porphyria Variegata, Susceptibility To

Protocoproporphyria

Porphyria Variegate

Porphyria South African Type

Pv

Porphyria, Variegate

Vp - [Variegate Porphyria]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PFDN2 RGD RGD:1591406
Mus musculus PFDN2 MGD MGI:1276111
Bos taurus PFDN2 VGNC VGNC:59188
Macaca mulatta PFDN2 VGNC VGNC:106469
Felis catus PFDN2 VGNC VGNC:68802
Canis familiaris PFDN2 VGNC VGNC:44440
Others PFDN2 NCBI