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  2. Lpar2 - lysophosphatidic acid receptor 2 Gene

Lpar2 - lysophosphatidic acid receptor 2 Gene

中文名称:溶血磷脂酸受体 2

种属: Mus musculus

同用名: Edg4; IPA2; LPA2

基因 ID: 53978 | 基因类型: protein coding

关于 Lpar2

Chromosome 8: 70,275,079-70,283,752 forward strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 270 orthologues, 18 paralogues and is associated with 10 phenotypes. Ubiquitous expression in testis adult (RPKM 4.), spleen adult (RPKM 3.8) and 25 other tissues.

功能概要

该基因编码的蛋白可启动 PDZ 域绑定活动。作用于 G 蛋白偶联受体信号通路的上游或内部; MAPK 级联的正调控;和 Rho 蛋白信号转导的正调控。位于谷氨酸能突触。是突触前活动区膜的组成部分。以多种结构表达,包括消化系统;鳃弓;中枢神经系统;淋巴系统腺体;和感觉器官。与人类 LPAR2(溶血磷脂酸受体 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables PDZ domain binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Located in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Lpar2 基因产物(1)

mRNA Protein Name
NM_020028.3 NP_064412.2 lysophosphatidic acid receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
15755723 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15755723 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15755723 MGI
acts upstream of or within positive regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
15755723 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19766573 MGI
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
19766573 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Lpar2 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (29 - 302)

7tm_GPCRs

7tm_GPCRs: cd14964 (31 - 55)

7tm_GPCRs

7tm_GPCRs: cd14964 (64 - 85)

7tm_GPCRs

7tm_GPCRs: cd14964 (101 - 123)

7tm_GPCRs

7tm_GPCRs: cd14964 (145 - 161)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (236 - 258)

7tm_GPCRs

7tm_GPCRs: cd14964 (270 - 295)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 2

LPA receptor 2

LPA-2

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

lysophosphatidic acid receptor Edg-4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lpar2 NCBI NCBI:9170