2. Gene
  3. DUS2 - dihydrouridine synthase 2 Gene

DUS2 - dihydrouridine synthase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二氢尿苷合酶 2

种属: Homo sapiens

同用名: SMM1; DUS2L; URLC8

基因 ID: 54920 | 基因类型: protein coding

关于 DUS2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,023,284-68,079,320 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues.

功能概要

该基因编码一种细胞质蛋白，可催化 tRNA D 环中的尿苷残基转化为二氢尿苷。由此产生的修饰碱基赋予 tRNA 增强的区域灵活性。编码的蛋白质可以通过抑制干扰素诱导的蛋白激酶来提高翻译速率。该基因与肺癌发生有关。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified Bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

DUS2 基因产物(3)

mRNA Protein Name
NM_001271762.2 NP_001258691.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1
NM_001271763.2 NP_001258692.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2
NM_017803.5 NP_060273.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

DUS2 蛋白结构

Dus

Dus: Dihydrouridine synthase (Dus) (15 - 329)

dsrm

dsrm: Double-stranded RNA binding motif (370 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

SMM1 homolog

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04048 DUS2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DUS2 VGNC VGNC:61658
Rattus norvegicus DUS2 RGD RGD:1305612
Macaca mulatta DUS2 VGNC VGNC:71908
Canis familiaris DUS2 VGNC VGNC:40124
Mus musculus DUS2 MGD MGI:1913619
Bos taurus DUS2 VGNC VGNC:28246
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