2. Gene
  3. DOK4 - docking protein 4 Gene

DOK4 - docking protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：对接蛋白 4

种属: Homo sapiens

同用名: IRS5; IRS-5

基因 ID: 55715 | 基因类型: protein coding

关于 DOK4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,471,922-57,487,322 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 7 paralogues. Ubiquitous expression in colon (RPKM 23.2), small intestine (RPKM 21.5) and 25 other tissues.

功能概要

预计参与 MAPK 级联和跨膜受体蛋白酪氨酸激酶信号通路的正调控。预计在神经系统发育的上游或内部起作用。预测位于胞质溶胶中。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in positive regulation of MAPK cascade and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DOK4 基因产物(16)

mRNA Protein Name
NM_001330556.2 NP_001317485.1 docking protein 4 isoform 2
NM_001369618.1 NP_001356547.1 docking protein 4 isoform 2
NM_001369619.1 NP_001356548.1 docking protein 4 isoform 1
NM_001369620.1 NP_001356549.1 docking protein 4 isoform 2
NM_001369621.1 NP_001356550.1 docking protein 4 isoform 1
NM_001394652.1 NP_001381581.1 docking protein 4 isoform 2
NM_001394653.1 NP_001381582.1 docking protein 4 isoform 2
NM_001394654.1 NP_001381583.1 docking protein 4 isoform 2
NM_001394655.1 NP_001381584.1 docking protein 4 isoform 2
NM_001394656.1 NP_001381585.1 docking protein 4 isoform 2
NM_001394657.1 NP_001381586.1 docking protein 4 isoform 1
NM_001394658.1 NP_001381587.1 docking protein 4 isoform 1
NM_001394659.1 NP_001381588.1 docking protein 4 isoform 1
NM_001394660.1 NP_001381589.1 docking protein 4 isoform 1
NM_001394661.1 NP_001381590.1 docking protein 4 isoform 1
NM_018110.5 NP_060580.2 docking protein 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOK4 蛋白结构

PH

PH: PH domain (8 - 108)

IRS

IRS: PTB domain (IRS-1 type) (137 - 230)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

docking protein 4

downstream of tyrosine kinase 4

关联疾病

疾病名称 别名
Nephronophthisis 3

NPHP3

Nph3

Adolescent Nephronophthisis

Nephronophthisis, Type 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03936 DOK4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DOK4 VGNC VGNC:40058
Bos taurus DOK4 VGNC VGNC:28168
Mus musculus DOK4 MGD MGI:2148865
Rattus norvegicus DOK4 RGD RGD:1310084
Felis catus DOK4 VGNC VGNC:61583
Macaca mulatta DOK4 VGNC VGNC:71867
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