2. Gene
  3. ADAP2 - ArfGAP with dual PH domains 2 Gene

ADAP2 - ArfGAP with dual PH domains 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有双 PH 域的 ArfGAP 2

种属: Homo sapiens

同用名: CENTA2; cent-b; HSA272195

基因 ID: 55803 | 基因类型: protein coding

关于 ADAP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,921,945-30,959,322 (from NCBI)

This gene has 11 transcripts (splice variants), 250 orthologues and 28 paralogues. Broad expression in spleen (RPKM 10.3), placenta (RPKM 9.9) and 23 other tissues.

功能概要

由该基因编码的蛋白质结合 β-微管蛋白并增加微管的稳定性。编码的蛋白质还可以转移到细胞膜并结合磷脂酰肌醇 3,4,5-三磷酸 (PtdInsP3) 和肌醇 1,3,4,5-四磷酸 (InsP4) 。此外，该蛋白是 ADP 核糖基化因子 6 的 GTP 酶激活蛋白，可能能够阻止某些 RNA 病毒的进入。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

ADAP2 基因产物(4)

mRNA Protein Name
NM_001346712.2 NP_001333641.1 arf-GAP with dual PH domain-containing protein 2 isoform 1
NM_001346714.2 NP_001333643.1 arf-GAP with dual PH domain-containing protein 2 isoform 3
NM_001346716.2 NP_001333645.1 arf-GAP with dual PH domain-containing protein 2 isoform 4
NM_018404.3 NP_060874.1 arf-GAP with dual PH domain-containing protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol 1,3,4,5 tetrakisphosphate binding IDA
IDA: 通过直接分析推断
14690521 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
14690521 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20098747 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heart development IEP
IEP: 通过表达模式推断
16138909 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14690521 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14690521 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAP2 蛋白结构

ArfGap

ArfGap: Putative GTPase activating protein for Arf (13 - 124)

PH_11

PH_11: Pleckstrin homology domain (258 - 357)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
蛋白主名 其他名称

arf-GAP with dual PH domain-containing protein 2

centaurin beta

关联疾病

疾病名称 别名
Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome

17q11 Microdeletion Syndrome

Neurofibromatosis Type 1 Microdeletion Syndrome

Van Asperen Syndrome

Del(17)(Q11)

Monosomy 17q11

Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Neurofibromatosis-Noonan Syndrome

NFNS

Neurofibromatosis Type 1

Neurofibromatosis With Noonan Phenotype

Nf1

Von Recklinghausen Disease

Neurofibromatosis Type 1-Noonan Syndrome

Noonan Neurofibromatosis Syndrome

Recklinghausen'S Disease

Noonan-Neurofibromatosis Syndrome

Fibromatosis Multiple Non Ossifying

Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

Jaffe Campanacci Syndrome

Type 1 Neurofibromatosis

Neurofibromatosis 1

Peripheral Neurofibromatosis

Recklinghausen Disease, Nerve

Jaffe-Campanacci Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00316 ADAP2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADAP2 RGD RGD:708487
Canis familiaris ADAP2 VGNC VGNC:37611
Felis catus ADAP2 VGNC VGNC:59605
Macaca mulatta ADAP2 VGNC VGNC:69430
Mus musculus ADAP2 MGD MGI:2663075
Bos taurus ADAP2 VGNC VGNC:25634
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z