PCDHB6 - protocadherin beta 6 Gene

中文名称：原钙粘蛋白 6

种属: Homo sapiens

同用名: PCDH-BETA6

关于 PCDHB6

功能概要

该基因是原钙粘蛋白β基因簇的成员，原钙粘蛋白β基因簇是在 5 号染色体上串联连接的三个相关基因簇之一。基因簇展示了一种不寻常的基因组组织，类似于 B 细胞和 T 细胞受体基因簇。与 alpha 和 gamma 簇不同，这些基因的转录本不共享共同的 3' 外显子。这些神经钙粘蛋白样细胞粘附蛋白是完整的质膜蛋白，很可能在特定细胞-细胞神经连接的建立和功能中发挥关键作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. Unlike the alpha and gamma clusters, the transcripts from these genes do not share common 3' exons. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell neural connections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]