SPPL2B - signal peptide peptidase like 2B Gene

中文名称：信号肽肽酶样 2B

种属: Homo sapiens

同用名: IMP4; PSH4; PSL1; IMP-4

基因 ID: 56928 | 基因类型: protein coding

关于 SPPL2B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,328,684-2,355,095 (from NCBI)

This gene has 14 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 13.2), duodenum (RPKM 10.9) and 25 other tissues.

功能概要

该基因编码天冬氨酸蛋白酶 GXGD 家族的一个成员。 GXGD 蛋白酶是跨膜蛋白，具有两个位于跨膜区域内的保守催化基序。这种酶定位于核内体、溶酶体和质膜。它切割肿瘤坏死因子 α 的跨膜结构域以释放细胞内结构域，从而触发先天性和适应性免疫途径中的细胞因子表达。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SPPL2B 基因产物(2)

mRNA	Protein	Name
NM_001077238.2	NP_001070706.1	signal peptide peptidase-like 2B isoform 3 precursor
NM_152988.3	NP_694533.1	signal peptide peptidase-like 2B isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables aspartic endopeptidase activity, intramembrane cleaving	IDA IDA: 通过直接分析推断	2313285	GOA
NOT enables aspartic endopeptidase activity, intramembrane cleaving	IMP IMP: 通过突变表型推断	16873890	GOA
enables aspartic endopeptidase activity, intramembrane cleaving	IMP IMP: 通过突变表型推断	19114711	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	2313285	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	15385547	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in membrane protein ectodomain proteolysis	IDA IDA: 通过直接分析推断	16829951	GOA
involved in membrane protein intracellular domain proteolysis	IDA IDA: 通过直接分析推断	16829951	GOA
involved in membrane protein intracellular domain proteolysis	IMP IMP: 通过突变表型推断	16829952	GOA
involved in membrane protein proteolysis	IDA IDA: 通过直接分析推断	2313285	GOA
involved in regulation of immune response	IMP IMP: 通过突变表型推断	16829952	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi-associated vesicle membrane	IDA IDA: 通过直接分析推断	17965014	GOA
located in cytoplasmic side of endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15385547	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	15998642	GOA
located in lumenal side of endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15385547	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	15998642	GOA
located in membrane	IDA IDA: 通过直接分析推断	2313285	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16829952	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

signal peptide peptidase-like 2B

SPP-like 2B

关联疾病

疾病名称

别名

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-111360	SPL-707	Inhibitor	99.64%	否
HY-RS13705	SPPL2B Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SPPL2B	VGNC	VGNC:35235
Rattus norvegicus	SPPL2B	RGD	RGD:1308556
Canis familiaris	SPPL2B	VGNC	VGNC:46759
Mus musculus	SPPL2B	MGD	MGI:1920468
Felis catus	SPPL2B	VGNC	VGNC:80726

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPPL2B - signal peptide peptidase like 2B Gene

关于 SPPL2B

功能概要

SPPL2B 基因产物(2)

关联疾病

直系同源

热门区域

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SPPL2B - signal peptide peptidase like 2B Gene

关于 SPPL2B

功能概要

SPPL2B 基因产物(2)

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z