2. Gene
  3. CASS4 - Cas scaffold protein family member 4 Gene

CASS4 - Cas scaffold protein family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Cas 支架蛋白家族成员 4

种属: Homo sapiens

同用名: CAS4; HEFL; HEPL; C20orf32

基因 ID: 57091 | 基因类型: protein coding

关于 CASS4

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,412,036-56,460,382 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 3 paralogues. Broad expression in lung (RPKM 5.8), appendix (RPKM 4.9) and 15 other tissues.

功能概要

启用蛋白酪氨酸激酶结合活性。参与多个过程，包括蛋白激酶 B 信号的正调节；蛋白酪氨酸激酶活性的正调节；底物粘附依赖性细胞扩散的正调控。位于粘着斑。细胞质的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CASS4 基因产物(4)

mRNA Protein Name
NM_001164114.2 NP_001157586.1 cas scaffolding protein family member 4 isoform b
NM_001164115.2 NP_001157587.1 cas scaffolding protein family member 4 isoform c
NM_001164116.2 NP_001157588.1 cas scaffolding protein family member 4 isoform a
NM_020356.4 NP_065089.2 cas scaffolding protein family member 4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
18256281 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
18256281 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
27677288 GOA
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
18256281 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
18256281 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23001926 GOA
located in cytoplasm IMP
IMP: 通过突变表型推断
27677288 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
18256281 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CASS4 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (18 - 66)

Serine_rich

Serine_rich: Serine rich protein interaction domain (435 - 593)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (597 - 785)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
蛋白主名 其他名称

cas scaffolding protein family member 4

HEF-like protein

关联疾病

疾病名称 别名
Astigmatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01977 CASS4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20870 Cass4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27387 Cass4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CASS4 VGNC VGNC:38741
Rattus norvegicus CASS4 RGD RGD:1310643
Bos taurus CASS4 VGNC VGNC:26789
Mus musculus CASS4 MGD MGI:2444482
Felis catus CASS4 VGNC VGNC:60389
Macaca mulatta CASS4 VGNC VGNC:70562
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