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  2. GPR158 - G protein-coupled receptor 158 Gene

GPR158 - G protein-coupled receptor 158 Gene

中文名称:G 蛋白偶联受体 158

种属: Homo sapiens

基因 ID: 57512 | 基因类型: protein coding

关于 GPR158

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:25,175,001-25,602,229 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue.

功能概要

预计可启用 G 蛋白偶联受体活性。预测作用于 G 蛋白偶联受体信号通路的上游或内部,以及蛋白定位到质膜。预测位于膜中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR158 基因产物(1)

mRNA Protein Name
NM_020752.3 NP_065803.2 probable G-protein coupled receptor 158 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled glycine receptor activity IDA
IDA: 通过直接分析推断
36996198 GOA
enables enzyme activator activity IDA
IDA: 通过直接分析推断
31189666 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
31189666 GOA
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
31189666 GOA
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
36996198 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
31189666 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR158 蛋白结构

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (427 - 667)

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  • 1215 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 158

关联疾病

疾病名称 别名
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas

Night Blindness, Congenital Stationary, Type 1b

Congenital Stationary Night Blindness 1b

CSNB1B

Night Blindness, Congenital Stationary, Complete, Autosomal Recessive

Csnb, Complete, Autosomal Recessive

Night Blindness, Congenital Stationary , 1b, Autosomal Recessive

Autosomal Recessive Complete Congenital Stationary Night Blindness

Congenital Stationary Night Blindness 1b Autosomal Recessive

Night Blindness, Congenital Stationary, 1b

Complete Autosomal Recessive Csnb

Complete Congenital Stationary Night Blindness Autosomal Recessive

Blindness, Night, Stationary, Congenital, Type 1b

Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPR158 VGNC VGNC:29564
Canis familiaris GPR158 VGNC VGNC:41410
Macaca mulatta GPR158 VGNC VGNC:103821
Rattus norvegicus GPR158 RGD RGD:1305841
Mus musculus GPR158 MGD MGI:2441697
Others GPR158 NCBI