2. Gene
  3. Pnkp - polynucleotide kinase 3'- phosphatase Gene

Pnkp - polynucleotide kinase 3'- phosphatase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PNK; 1810009G08Rik

基因 ID: 59047 | 基因类型: protein coding

关于 Pnkp

功能概要

Enables ubiquitin ligase-substrate adaptor activity. Involved in cellular response to DNA damage stimulus and protein K63-linked ubiquitination. Part of SCF ubiquitin Ligase complex. Is active in site of double-strand break. Is expressed in cerebellum; cerebral cortex; liver; and spleen. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2 and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Pnkp 基因产物(4)

mRNA Protein Name
NM_001290764.1 NP_001277693.1 bifunctional polynucleotide phosphatase/kinase isoform a
NM_001290766.1 NP_001277695.1 bifunctional polynucleotide phosphatase/kinase isoform b
NM_001290767.1 NP_001277696.1 bifunctional polynucleotide phosphatase/kinase isoform c
NM_021549.3 NP_067524.2 bifunctional polynucleotide phosphatase/kinase isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
26774286 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
26774286 MGI
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
26774286 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SCF ubiquitin ligase complex IDA
IDA: 通过直接分析推断
26774286 MGI
is active in site of double-strand break IDA
IDA: 通过直接分析推断
26774286 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bifunctional polynucleotide phosphatase/kinase

DNA 5'-kinase/3'-phosphatase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10778 PNKP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19631 Pnkp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26126 Pnkp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pnkp NCBI NCBI:11284
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